Drug development, Brazilian biodiversity and political choices: Where are we heading?

PMP Ferreira, DDR Arcanjo… - Journal of Toxicology and …, 2023 - Taylor & Francis
The aim of this review was to (i) acknowledge structural advantages of natural products
(NPs) for designing therapeutic drugs;(ii) emphasize how wildlife conservation is socially …

Dual effects of alpha-hydroxy acids on the skin

SC Tang, JH Yang - Molecules, 2018 - mdpi.com
AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid.
AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often …

Bufalin for an innovative therapeutic approach against cancer

L Soumoy, GE Ghanem, S Saussez, F Journe - Pharmacological Research, 2022 - Elsevier
Bufalin is an endogenous cardiotonic steroid, first discovered in toad venom but also found
in the plasma of healthy humans, with anti-tumour activities in different cancer types. The …

Toad venom: A comprehensive review of chemical constituents, anticancer activities, and mechanisms

FJ Li, JH Hu, X Ren, CM Zhou, Q Liu… - Archiv der …, 2021 - Wiley Online Library
Toad venom, a traditional natural medicine, has been used for hundreds of years in China
for treating different diseases. Many studies have been performed to elucidate the …

Metabolites from Bufo gargarizans (Cantor, 1842): A review of traditional uses, pharmacological activity, toxicity and quality control

X Zhan, H Wu, H Wu, R Wang, C Luo, B Gao… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Bufo gargarizans (Cantor, 1842)(BGC), a
traditional medicinal animal distributed in many provinces of China, is well known for the …

Protoplast Isolation and Shoot Regeneration from Protoplast-Derived Callus of Petunia hybrida Cv. Mirage Rose

HH Kang, AH Naing, CK Kim - Biology, 2020 - mdpi.com
Despite the increasing use of protoplasts in plant biotechnology research, shoot
regeneration from protoplasts remains challenging. In this study, we investigated the factors …

[PDF][PDF] Biosynthesis of zinc oxide and silver/zinc oxide nanoparticles from Urginea epigea for antibacterial and antioxidant applications

MC Jobe, DMN Mthiyane, M Mwanza, DC Onwudiwe - Heliyon, 2022 - cell.com
Zinc oxide (ZnO) and silver-zinc oxide (Ag/ZnO) nanocomposite were synthesized by a
green method using Zn (CH 3 COO) 2 and AgNO 3 as precursors for zinc and silver …

Chemistry and the potential antiviral, anticancer, and anti-inflammatory activities of cardiotonic steroids derived from toads

HR El-Seedi, N Yosri, B El-Aarag, SH Mahmoud… - Molecules, 2022 - mdpi.com
Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000
years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of …

A salamander's toxic arsenal: review of skin poison diversity and function in true salamanders, genus Salamandra

T Lüddecke, S Schulz, S Steinfartz, M Vences - The Science of Nature, 2018 - Springer
Terrestrial salamanders of the genus Salamandra represent one of the most prominent
groups of amphibians. They are mainly distributed across Europe but also reach Northern …

Bufadienolides preferentially inhibit aminopeptidase N among mammalian metallo-aminopeptidases; relationship with effects on human melanoma MeWo cells

IP Alonso, LR Méndez, FA García… - International Journal of …, 2023 - Elsevier
Bufadienolides are steroids that inhibit Na+/K+-ATPase; recent evidence shows that bufalin
inhibits the activity of porcine aminopeptidase N (pAPN). We evaluated the selectivity of …