The role of hypoxia-inducible factors in metabolic diseases

FJ Gonzalez, C Xie, C Jiang - Nature Reviews Endocrinology, 2019 - nature.com
Abstract Hypoxia-inducible factors (HIFs), a family of transcription factors activated by
hypoxia, consist of three α-subunits (HIF1α, HIF2α and HIF3α) and one β-subunit (HIF1β) …

[HTML][HTML] Biomarkers of Nutrition for Development (BOND)—iron review

S Lynch, CM Pfeiffer, MK Georgieff, G Brittenham… - The Journal of …, 2018 - Elsevier
This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for
Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant …

The hematologic consequences of obesity

JC Purdy, JJ Shatzel - European journal of haematology, 2021 - Wiley Online Library
The prevalence of obesity is increasing and progressively influencing physician‐patient
interactions. While there is a sizable amount of data demonstrating that obesity is a state of …

Obesity as a risk factor for COVID-19: an overview

RW Alberca, LM Oliveira, ACCC Branco… - Critical reviews in …, 2021 - Taylor & Francis
The current coronavirus disease-2019 (COVID-19) pandemic presents a huge challenge for
health-care systems worldwide. Many different risk factors are associated with disease …

[HTML][HTML] Iron and diabetes risk

JA Simcox, DA McClain - Cell metabolism, 2013 - cell.com
Iron overload is a risk factor for diabetes. The link between iron and diabetes was first
recognized in pathologic conditions—hereditary hemochromatosis and thalassemia—but …

Childhood dual burden of under-and overnutrition in low-and middle-income countries: a critical review

E Tzioumis, LS Adair - Food and nutrition bulletin, 2014 - journals.sagepub.com
Background In low-and middle-income countries, the distribution of childhood nutritional
diseases is shifting from a predominance of undernutrition to a dual burden of under-and …

[HTML][HTML] Obesity as an emerging risk factor for iron deficiency

E Aigner, A Feldman, C Datz - Nutrients, 2014 - mdpi.com
Iron homeostasis is affected by obesity and obesity-related insulin resistance in a many-
facetted fashion. On one hand, iron deficiency and anemia are frequent findings in subjects …

Obesity and surgical wound healing: a current review

YN Pierpont, TP Dinh, RE Salas… - International …, 2014 - Wiley Online Library
Objective. The correlation between obesity and deficient wound healing has long been
established. This review examines the current literature on the mechanisms involved in …

Obesity and iron deficiency: a quantitative meta‐analysis

L Zhao, X Zhang, Y Shen, X Fang, Y Wang… - Obesity …, 2015 - Wiley Online Library
Hypoferraemia (ie iron deficiency) was initially reported among obese individuals several
decades ago; however, whether obesity and iron deficiency are correlated remains unclear …

[HTML][HTML] Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity

Z Zhang, JB Funcke, Z Zi, S Zhao, LG Straub, Y Zhu… - Cell metabolism, 2021 - cell.com
Iron overload is positively associated with diabetes risk. However, the role of iron in adipose
tissue remains incompletely understood. Here, we report that transferrin-receptor-1 …