During random locomotion, human neutrophils and Dictyostelium discoideum amoebae
repeatedly extend and retract cytoplasmic processes. During directed cell migration …

Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated
process that involves gradient sensing, motility, and polarity. Most of our understanding of …

Cyclic AMP (cAMP) plays a key regulatory role in most types of cells; however, the pathways
controlled by cAMP may present important differences between organisms and between …

▪ Abstract Dictyostelium is an accessible organism for studies of signaling via
chemoattractant receptors. Chemoattractant-mediated signaling events and components are …

This review focuses primarily on our current understanding of the structure and function of
GAF domains in cyclic nucleotide phosphodiesterases (PDEs). The GAF domain was …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

Dictyostelium conventional myosin (myosin II) is an abundant protein that plays a role in
various cellular processes such as cytokinesis, cell protrusion and development. This review …

Abstract cAMP plays a pivotal role in control of cell movement, differentiation and response
to stress in all phases of the Dictyostelium life cycle. The multitudinous functions of cAMP …

In plants, nitric oxide (NO)-mediated 3′, 5′-cyclic guanosine monophosphate (cGMP)
synthesis plays an important role during pathogenic stress response, stomata closure upon …

[Frontiers in Bioscience 10, 1485-1498, May 1, 2005] 1485 GUANYLYL CYCLASES ACROSS
THE TREE OF LIFE Pauline Schaap School of Lif Page 1 [Frontiers in Bioscience 10 …