Purpose: Our previous studies suggested that CYP46A1 and 24S‐hydroxycholesterol
(24SOH) may be associated with glaucoma. Loss of CYP46A1‐expressing retinal ganglion …

Glaucoma, frequently associated with elevated intraocular pressure (IOP), is one of the
leading causes of blindness. We sought to establish a mouse model of ocular hypertension …

A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The
discovered compounds had excellent enzyme and cellular potency, high kinase selectivity …

Purpose To characterize differences in retinal ganglion cell (RGC) function in mouse strains
relevant to disease models. C57BL/6J (B6) and DBA/2J (D2) are the two most common …

Peptide probes for imaging retinal ganglion cell (RGC) apoptosis consist of a cell-
penetrating peptide targeting moiety and a fluorophore-quencher pair flanking an effector …

Purpose.: To characterize the labeling of apoptotic cells with a molecular probe of bis (zinc
(II)-dipicolylamine)(Zn-DPA) conjugated with a fluorescent reporter in a rat model of retinal …

A reliable method of creating chronic elevation of intraocular pressure (IOP) in rodents is an
important tool in reproducing and studying the mechanisms of optic nerve injury that occur in …

Animal models of ocular hypertension are important tools for glaucoma studies. Both acute
transient models and chronic models of ocular hypertension may be useful to investigate …

Purpose: The study aimed to provide a quantitative description of aqueous humor dynamics
in healthy rat eyes. Methods: One eye of 26 anesthetized adult Brown-Norway rats was …

Purpose.: To evaluate the potential neuroprotective effects of C-type natriuretic peptide
(CNP) on rat retinal ganglion cells (RGCs). Methods.: Cultured adult rat retinal cells were …