[HTML][HTML] Biological roles and therapeutic potential of circular RNAs in osteoarthritis

X Mao, Y Cao, Z Guo, L Wang, C Xiang - Molecular Therapy-Nucleic Acids, 2021 - Elsevier
Osteoarthritis (OA) is a common and disabling joint disorder that is mainly characterized by
cartilage degeneration and narrow joint spaces. The regulatory functions of non-coding …

[HTML][HTML] Epigenetic modifications in spinal ligament aging

Q Xiang, Y Zhao, J Lin, S Jiang, W Li - Ageing Research Reviews, 2022 - Elsevier
Spinal stenosis is a common degenerative spine disorder in the aged population and the
spinal ligament aging is a main contributor to this chronic disease. However, the underlying …

[HTML][HTML] Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis

G Mao, Y Xu, D Long, H Sun, H Li, R Xin… - Stem Cell Research & …, 2021 - Springer
Objectives Aberrations in exosomal circular RNA (circRNA) expression have been identified
in various human diseases. In this study, we investigated whether exosomal circRNAs could …

[HTML][HTML] Crosstalk among circRNA/lncRNA, miRNA, and mRNA in osteoarthritis

H Kong, ML Sun, XA Zhang, XQ Wang - Frontiers in Cell and …, 2021 - frontiersin.org
Osteoarthritis (OA) is a joint disease that is pervasive in life, and the incidence and mortality
of OA are increasing, causing many adverse effects on people's life. Therefore, it is very vital …

The role of autophagy in osteoarthritic cartilage

WC Kao, JC Chen, PC Liu, CC Lu, SY Lin, SC Chuang… - Biomolecules, 2022 - mdpi.com
Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with
age being the main risk factor, and degeneration of articular cartilage is the main focus for …

MicroRNA expression in osteoarthritis: A meta-analysis

H Liu, L Yan, X Li, D Li, G Wang, NN Shen, JJ Li… - Clinical and …, 2023 - Springer
Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases globally, leading
to chronic disability and poor prognosis. One of the approaches for optimizing OA treatment …

[HTML][HTML] Studies on the Role of circRNAs in Osteoarthritis

W Wu, J Zou - BioMed Research International, 2021 - hindawi.com
Objective. Provide a reference to elucidate the mechanism of circRNAs regulating
osteoarthritis (OA) and the clinical treatment. Methods. Herein, articles about circRNAs (hsa …

CircATRNL1 protects against osteoarthritis by targeting miR-153-3p and KLF5

KF Wang, ZW Shi, DM Dong - International Immunopharmacology, 2021 - Elsevier
Background Osteoarthritis (OA) is characterized by chondrocyte injury. Circular RNAs
(circRNAs) are involved in the pathogenesis of various diseases, including OA. The purpose …

Regulation of circADAMTS6-miR-324-5p-PIK3R3 ceRNA pathway may be a novel mechanism of IL-1β-induced osteoarthritic chondrocytes

L Shen, C Ji, J Lin, H Yang - Journal of Bone and Mineral Metabolism, 2022 - Springer
Introduction A disintegrin and metallopeptidase with thrombospondin type 1 motif 6
(ADAMTS6)-derived circular RNA (circADAMTS6; hsa_circ_0008667) is a novel regulator in …

[HTML][HTML] Knockdown of Circ_0037658 alleviates IL-1β-induced osteoarthritis progression by serving as a sponge of miR-665 to regulate ADAMTS5

N Li, Y Wang, X Wu - Frontiers in Genetics, 2022 - frontiersin.org
Background: Osteoarthritis (OA) is a chronic musculoskeletal degeneration disease, which
brings great pain to patients and a tremendous burden on the world's medical resources …