Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

One in 10 persons in the world aged 40 years and older will develop the syndrome of
HFpEF (heart failure with preserved ejection fraction), the most common form of chronic …

Myocardial infarction (MI) is a major disease posing a significant threat to human health, as it
leads to necrosis of numerous cardiomyocytes (CMs), left ventricle dilation, and cardiac …

The gasotransmitters are a family of gaseous signaling molecules which are produced
endogenously and act at specific receptors to play imperative roles in physiologic and …

Impaired diabetic wounds are serious pathophysiological complications associated with
persistent microbial infections including failure in the closure of wounds, and the cause of a …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Outcomes for heart failure (HF) patients remain suboptimal. No known therapy improves
mortality in acute HF and HF with preserved ejection fraction; the most recent HF trial results …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Background Metformin, the eldest and most widely used glucose lowering drug, is likely to
be effective also on cardiac and vascular disease prevention. Nonetheless, uncertainty still …

Septic shock, the most severe complication of sepsis, accounts for∼ 10% of all admissions
to intensive care. Our understanding of its complex pathophysiology remains incomplete but …