Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke? Discordance between randomised controlled trials and observational studies

AJ Scheen - Diabetes & Metabolism, 2023 - Elsevier
Stroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular
complication has been less carefully investigated than the risk of cardiovascular mortality …

[HTML][HTML] Renal effects of GLP-1 receptor agonists and tirzepatide in individuals with type 2 diabetes: seeds of a promising future

I Caruso, F Giorgino - Endocrine, 2024 - Springer
Purpose Chronic kidney disease (CKD) is one of the most common complications of type 2
diabetes (T2D), and CKD-related disability and mortality are increasing despite the recent …

[HTML][HTML] Cardiovascular and renal outcomes with SGLT2 inhibitors: Real-life observational studies in older patients with type 2 diabetes: SGLT2 inhibitors in elderly …

AJ Scheen - Diabetes Epidemiology and Management, 2023 - Elsevier
Patients with type 2 diabetes mellitus (T2DM) are exposed to a high risk of atherosclerotic
cardiovascular disease, heart failure and chronic kidney disease. The incidence of these …

[HTML][HTML] Impact of chronic GLP-1 RA and SGLT-2I therapy on in-hospital outcome of diabetic patients with acute myocardial infarction

F Trombara, N Cosentino, A Bonomi… - Cardiovascular …, 2023 - Springer
Background Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium glucose
cotransporter-2 inhibitors (SGLT-2i) demonstrated cardiovascular and renal protection …

The association between sodium/glucose cotransporter-2 inhibitors and adverse clinical events in patients with chronic kidney disease: a systematic review and meta …

Y Zhou, FR Wang, FF Wen, C Li, TT Ye - Acta Cardiologica, 2024 - Taylor & Francis
Background The purpose of this systematic review and meta-analysis was to evaluate the
common clinical adverse events associated with sodium/glucose cotransporter-2 inhibitor …

Role of GLP-1 receptor agonist in diabetic cardio-renal disorder: Recent updates of clinical and pre-clinical evidence

S Seksaria, BJ Dutta, M Kaur, GD Gupta… - Current Diabetes …, 2024 - ingentaconnect.com
Cardiovascular complications and renal disease is the growing cause of mortality in patients
with diabetes. The subversive complications of diabetes such as hyperglycemia …

Comparative safety and cardiovascular effectiveness of sodium‐glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists in nursing homes

MR Riester, AR Zullo, R Joshi… - Diabetes, Obesity …, 2024 - Wiley Online Library
Aim Studies examining the safety and effectiveness of sodium‐glucose cotransporter‐2
inhibitors (SGLT2is) versus glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) among …

Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium–Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor …

G Gallo, M Volpe - International Journal of Molecular Sciences, 2024 - mdpi.com
Different multifactorial pathophysiological processes are involved in the development of
heart failure (HF), including neurohormonal dysfunction, the hypertrophy of cardiomyocytes …

[HTML][HTML] Cardiorenal effectiveness of empagliflozin vs. glucagon-like peptide-1 receptor agonists: final-year results from the EMPRISE study

PT Htoo, H Tesfaye, S Schneeweiss, DJ Wexler… - Cardiovascular …, 2024 - Springer
No randomized clinical trials have directly compared the cardiorenal effectiveness of
empagliflozin and GLP-1RA agents with demonstrated cardioprotective effects in patients …

SGLT2 Inhibitors vs GLP-1 Receptor Agonists and Clinical Outcomes in Patients With Diabetes With/Without Atrial Fibrillation

YH Chan, TF Chao, SW Chen, HF Lee… - The Journal of …, 2024 - academic.oup.com
Context The coexistence of diabetes mellitus and atrial fibrillation (AF) is associated with
substantial risks of adverse cardiovascular events. Objective The relevant outcomes …