Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

The key pathological hallmarks—extracellular plaques and intracellular neurofibrillary
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …

Nanotechnology is one of the scientific advances in technology. Nanoparticles (NPs) are
small materials ranging from 1 to 100 nm. When the shape of the supplied nanoparticles …

Alzheimer's disease (AD) is characterised by synaptic dysfunction accompanied by the
microscopically visible accumulation of pathological protein deposits and cellular dystrophy …

Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is a
neurodegenerative disorder characterised by a progressive decline in cognitive function that …

The gastrointestinal tract communicates with the nervous system through a bidirectional
network of signaling pathways called the gut-brain axis, which consists of multiple …

In recent years, advances in science and technology have improved our quality of life,
enabling us to tackle diseases and increase human life expectancy. However, longevity is …

Ethnopharmacological relevance Senegenin (SEN), an active compound extracted from the
traditional Chinese herb Polygala tenuifolia Willd.(a species in the genus Polygala, family …

In a healthy physiological context, astrocytes are multitasking cells contributing to central
nervous system (CNS) homeostasis, defense, and immunity. In cell culture or rodent models …

When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from
the brains of Alzheimer's disease (AD) patients or transgenic AD mouse models seed …