Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and
complex inheritance. In the past decade, successful identification of numerous susceptibility …

Olanzapine, aripiprazole and risperidone are atypical antipsychotics or neuroleptics widely
used for schizophrenia treatment. They induce various adverse drug reactions depending …

The activity of cytochrome P450 enzymes is influenced by genetic and nongenetic factors;
hence, the metabolism of exogenous psychotropic medications and potentially some …

Purpose To study if second-generation antipsychotic (S-GA) use during the first trimester of
pregnancy is associated with an increased risk of major congenital malformations (MCM) …

Atorvastatin, prescribed for the treatment of hypercholesterolemia, demonstrated
overwhelming benefits in reducing cardiovascular morbidity and mortality. However, many …

Genetic polymorphism in olanzapine-metabolizing enzymes, transporters and drug targets is
associated with alterations in safety and efficacy. The aim of this systematic review is to …

Diazepam is a benzodiazepine (BZD) used worldwide for a variety of conditions. Long-term
use of diazepam increases the risk for developing tolerance and dependence and for the …

Schizophrenia (SCZ) is a complex psychiatric disorder of multifactorial origin, in which both
genetic and environmental factors have an impact on its onset, course, and outcome. Large …

Olanzapine is a commonly prescribed atypical antipsychotic agent for treatment of patients
with schizophrenia and bipolar disorders. Previous in vitro studies using human liver …

Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional
dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease. In this study, we …