A guide to membraneless organelles and their various roles in gene regulation

T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …

Modulating biomolecular condensates: a novel approach to drug discovery

DM Mitrea, M Mittasch, BF Gomes, IA Klein… - Nature Reviews Drug …, 2022 - nature.com
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

[HTML][HTML] Game changers in science and technology-now and beyond

UAK Betz, L Arora, RA Assal, H Azevedo… - … Forecasting and Social …, 2023 - Elsevier
The recent devastating pandemic has drastically reminded humanity of the importance of
constant scientific and technological progress. A strong interdisciplinary dialogue between …

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

H Zhang, X Ji, P Li, C Liu, J Lou, Z Wang… - Science China Life …, 2020 - Springer
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates

XM Liu, L Ma, R Schekman - Elife, 2021 - elifesciences.org
Exosomes may mediate cell-to-cell communication by transporting various proteins and
nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched …

Genetic variation associated with condensate dysregulation in disease

SF Banani, LK Afeyan, SW Hawken, JE Henninger… - Developmental cell, 2022 - cell.com
A multitude of cellular processes involve biomolecular condensates, which has led to the
suggestion that diverse pathogenic mutations may dysregulate condensates. Although proof …

The integral role of RNA in stress granule formation and function

D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Stress-related biomolecular condensates in plants

J Solis-Miranda, M Chodasiewicz, A Skirycz… - The Plant …, 2023 - academic.oup.com
Biomolecular condensates are membraneless organelle-like structures that can concentrate
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …

Protein phase separation and its role in tumorigenesis

S Jiang, JB Fagman, C Chen, S Alberti, B Liu - Elife, 2020 - elifesciences.org
Cancer is a disease characterized by uncontrolled cell proliferation, but the precise
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …

Phase transitions in chemically fueled, multiphase complex coacervate droplets

C Donau, F Späth, M Stasi, AM Bergmann… - Angewandte …, 2022 - Wiley Online Library
Membraneless organelles are droplets in the cytosol that are regulated by chemical
reactions. Increasing studies suggest that they are internally organized. However, how these …