A guide to membraneless organelles and their various roles in gene regulation
T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …
Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
[HTML][HTML] Game changers in science and technology-now and beyond
UAK Betz, L Arora, RA Assal, H Azevedo… - … Forecasting and Social …, 2023 - Elsevier
The recent devastating pandemic has drastically reminded humanity of the importance of
constant scientific and technological progress. A strong interdisciplinary dialogue between …
constant scientific and technological progress. A strong interdisciplinary dialogue between …
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates
Exosomes may mediate cell-to-cell communication by transporting various proteins and
nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched …
nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched …
Genetic variation associated with condensate dysregulation in disease
A multitude of cellular processes involve biomolecular condensates, which has led to the
suggestion that diverse pathogenic mutations may dysregulate condensates. Although proof …
suggestion that diverse pathogenic mutations may dysregulate condensates. Although proof …
The integral role of RNA in stress granule formation and function
D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …
(RNP) assemblies whose primary function is to promote cell survival by condensing …
Stress-related biomolecular condensates in plants
J Solis-Miranda, M Chodasiewicz, A Skirycz… - The Plant …, 2023 - academic.oup.com
Biomolecular condensates are membraneless organelle-like structures that can concentrate
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …
Protein phase separation and its role in tumorigenesis
Cancer is a disease characterized by uncontrolled cell proliferation, but the precise
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …
Phase transitions in chemically fueled, multiphase complex coacervate droplets
Membraneless organelles are droplets in the cytosol that are regulated by chemical
reactions. Increasing studies suggest that they are internally organized. However, how these …
reactions. Increasing studies suggest that they are internally organized. However, how these …