Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Aging is an inevitable outcome of life, characterized by a progressive decline in tissue and
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …

Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information‐containing factors, other …

Abstract Purpose of Review Bone remodeling is a diverse field of study with many direct
clinical applications; past studies have implicated epigenetic alterations as key factors of …

Objective The purpose of this review is to describe highlights from original research
publications related to osteoarthritis (OA), epigenetics and genomics with the intention of …

Osteoporosis, characterised by low bone mass, poor bone structure, and an increased risk
of fracture, is a major public health problem. There is increasing evidence that the influence …

Genetic susceptibility, together with old age, female sex, and low bone mineral density
(BMD) are amongst the strongest determinants of fracture risk. Tmost recent large-scale …

There is mounting evidence in the literature that mesenchymal stromal/stem cell (MSC) like
populations derived from different tissues, undergo epigenetic changes during aging …

Thus far, there are more than known 150 modifications to RNA, in which common internal
modifications of mRNA include N6-methyladenosine (m6A), N1-methyladenosine, and 5 …

Despite the remarkable regenerative capacity of skeletal tissues, nonunion of bone and
failure of fractures to heal properly presents a significant clinical concern. Stem and …