[HTML][HTML] Bone morphogenetic protein‑7 upregulates genes associated with osteoblast differentiation, including collagen I, Sp7 and IBSP in gingiva‑derived stem cells
H Lee, SK Min, Y Song, YH Park… - Experimental and …, 2019 - spandidos-publications.com
The present study was performed to evaluate the effects of short‑term application of bone
morphogenetic protein‑7 (BMP‑7) on human gingiva‑derived mesenchymal stem cells with …
morphogenetic protein‑7 (BMP‑7) on human gingiva‑derived mesenchymal stem cells with …
Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile
LE van der Wagen, A Miranda-Bedate… - Bone marrow …, 2020 - nature.com
Mesenchymal Stromal Cells (MSC) are the most frequently used advanced therapy
medicinal product to date [1] and have been reported as a promising treatment option for …
medicinal product to date [1] and have been reported as a promising treatment option for …
Epigenetics of skeletal diseases
A Del Real, L Riancho-Zarrabeitia… - Current Osteoporosis …, 2018 - Springer
Abstract Purpose of Review Epigenetic mechanisms modify gene activity in a stable manner
without altering DNA sequence. They participate in the adaptation to the environment, as …
without altering DNA sequence. They participate in the adaptation to the environment, as …
[HTML][HTML] Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway
J Ying, T Xu, C Wang, H Jin, P Tong, J Guan… - JCI insight, 2020 - ncbi.nlm.nih.gov
We previously established that DNA methyltransferase 3b (Dnmt3b) is the sole Dnmt
responsive to fracture repair and that Dnmt3b expression is induced in progenitor cells …
responsive to fracture repair and that Dnmt3b expression is induced in progenitor cells …
Omics analysis of human bone to identify genes and molecular networks regulating skeletal remodeling in health and disease
S Reppe, HK Datta, KM Gautvik - Bone, 2017 - Elsevier
The skeleton is a metabolically active organ throughout life where specific bone cell activity
and paracrine/endocrine factors regulate its morphogenesis and remodeling. In recent …
and paracrine/endocrine factors regulate its morphogenesis and remodeling. In recent …
Differential association of mitochondrial DNA haplogroups J and H with the methylation status of articular cartilage: potential role in apoptosis and metabolic and …
E Cortés‐Pereira, J Fernández‐Tajes… - Arthritis & …, 2019 - Wiley Online Library
Objective To analyze the influence of mitochondrial genome variation on the DNA
methylome of articular cartilage. Methods DNA methylation profiling was performed using …
methylome of articular cartilage. Methods DNA methylation profiling was performed using …
[PDF][PDF] DNA 甲基化与骨代谢调节及骨质疏松症研究进展
牛亚丹， 林伊荷， 张汉清， 陶涛， 徐雷艇 - 生命科学, 2020 - lifescience.sinh.ac.cn
骨质疏松症的根本病因是由于多种因素导致成骨细胞介导的骨形成与破骨细胞介导的骨吸收
过程之间的负平衡, 引起骨质进行性丢失, 骨密度降低, 骨脆性增加, 进而导致骨折风险增加 …
过程之间的负平衡, 引起骨质进行性丢失, 骨密度降低, 骨脆性增加, 进而导致骨折风险增加 …
Epigenetics of bone diseases
L Michou - Joint Bone Spine, 2018 - Elsevier
Histone deacetylation, DNA methylation, and micro-RNAs (miRNAs) are the three main
epigenetic mechanisms that regulate gene expression. All the physiological processes …
epigenetic mechanisms that regulate gene expression. All the physiological processes …
[HTML][HTML] Effects of systemic or local administration of mesenchymal stem cells from patients with osteoporosis or osteoarthritis on femoral fracture healing in a mouse …
E Laguna, MI Pérez-Núñez, Á Del Real, G Menéndez… - Biomolecules, 2022 - mdpi.com
The purpose of this study was to analyze the regenerative capacity of mesenchymal stem
cells (MSCs) in the treatment of fractures. MSCs extracted from patients with osteoporotic hip …
cells (MSCs) in the treatment of fractures. MSCs extracted from patients with osteoporotic hip …
hUC-MSCs: evaluation of acute and long-term routine toxicity testing in mice and rats
J Xu, G Liu, X Wang, Y Hu, H Luo, L Ye, Z Feng, C Li… - Cytotechnology, 2022 - Springer
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are present in human
umbilical connective tissue and can differentiate into various cell types. Our previous studies …
umbilical connective tissue and can differentiate into various cell types. Our previous studies …