This review describes the most recent 'omics' studies in OA research, their conclusions, and
discuss those remaining challenges. Still many validation studies must be performed in …

Despite the great advance of bone tissue engineering in the last few years, repair of bone
defects remains a major problem. Low cell engraftment and dose-dependent side effects …

Benzene is a global pollutant and has been established to cause leukemia. To better
understand the role of DNA methylation in benzene toxicity, peripheral blood mononuclear …

Purpose Previous studies have shown that DNA methyltransferase 3b (Dnmt3b) is the only
Dnmt responsive to fracture repair and Dnmt3b ablation in Prx1-positive stem cells and …

Bone has a robust regenerative potential, but its capacity to repair critical-sized bone defects
is limited. In recent years, stem cells have attracted significant interest for their potential in …

Purpose Human mesenchymal stem cells (MSCs) have the ability to differentiate into bone-
forming osteoblasts. The aim of this study was to elucidate if MSCs from patients with OP …

The integration of multi-omics data can greatly facilitate the advancement of research in Life
Sciences by highlighting new interactions. However, there is currently no widespread …

Mesenchymal stem cell (MSC) transplantation has emerged as a promising approach for
bone regeneration. Importantly, the beneficial effects of MSCs can be improved by …

The evidence sustaining the regenerative properties of mesenchymal stem cells'(MSCs)
secretome has prompted a paradigm change, where MSCs have shifted from being …

Massive genetic compendiums such as the UK Biobank have become an invaluable
resource for identifying genetic variants that are associated with complex diseases. Due to …