[HTML][HTML] A molecular approach in drug development for Alzheimer's disease
S Agatonovic-Kustrin, C Kettle, DW Morton - Biomedicine & …, 2018 - Elsevier
An increase in dementia numbers and global trends in population aging across the world
prompts the need for new medications to treat the complex biological dysfunctions, such as …
prompts the need for new medications to treat the complex biological dysfunctions, such as …
High-throughput pKa screening and prediction amenable for ADME profiling
H Wan, J Ulander - Expert opinion on drug metabolism & toxicology, 2006 - Taylor & Francis
Recent technological advances have made it possible for several new p K a assays to be
used in drug screening. In this review, a critical overview is provided of current new …
used in drug screening. In this review, a critical overview is provided of current new …
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-β-lactam β-lactamase inhibitor
T Stachyra, MC Péchereau, JM Bruneau… - Antimicrobial agents …, 2010 - Am Soc Microbiol
ABSTRACT NXL104 is a potent inhibitor of class A and C serine β-lactamases, including
KPC carbapenemases. Native and NXL104-inhibited TEM-1 and P99 β-lactamases …
KPC carbapenemases. Native and NXL104-inhibited TEM-1 and P99 β-lactamases …
Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo [d] thiazoles as cholinesterase inhibitors
A Imramovský, V Pejchal, Š Štěpánková… - Bioorganic & medicinal …, 2013 - Elsevier
A series of novel cholinesterase inhibitors based on 2-substituted 6-fluorobenzo [d] thiazole
were synthesised and characterised by IR, 1H, 13C and 19F NMR spectroscopy and HRMS …
were synthesised and characterised by IR, 1H, 13C and 19F NMR spectroscopy and HRMS …
[HTML][HTML] Acetylcholinesterase-Inhibiting Activity of Salicylanilide N-Alkylcarbamates and Their Molecular Docking
A Imramovsky, S Stepankova, J Vanco, K Pauk… - Molecules, 2012 - mdpi.com
A series of twenty-five novel salicylanilide N-alkylcarbamates were investigated as potential
acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit …
acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit …
Design and synthesis of garlic-related unsymmetrical thiosulfonates as potential Alzheimer's disease therapeutics: In vitro and in silico study
K Zilbeyaz, A Oztekin, EG Kutluana - Bioorganic & Medicinal Chemistry, 2021 - Elsevier
Garlic contains a wide range of organosulfur compounds, which exhibit a broad spectrum of
biological activities. Amongst the sulfur-containing compounds in garlic, the thiosulfonates …
biological activities. Amongst the sulfur-containing compounds in garlic, the thiosulfonates …
Ortho Effects for Inhibition Mechanisms of Butyrylcholinesterase by o-Substituted Phenyl N-Butyl Carbamates and Comparison with Acetylcholinesterase …
G Lin, YR Lee, YC Liu, YG Wu - Chemical research in toxicology, 2005 - ACS Publications
Phenyl carbamates are used to treat Alzheimer's disease. These compounds inhibit
acetylcholinesterase and butyrylcholinesterase. The goal of this work was to determine the …
acetylcholinesterase and butyrylcholinesterase. The goal of this work was to determine the …
On the number of EINECS compounds that can be covered by (Q) SAR models for acute toxicity
The new EU legislation for managing chemicals called REACH aims to fill in gaps in toxicity
information that exist for the chemicals listed on the European Inventory of Existing Chemical …
information that exist for the chemicals listed on the European Inventory of Existing Chemical …
QSARs for Peripheral Anionic Site of Butyrylcholinesterase with Inhibitions by 4‐Acyloxy‐biphenyl‐4′‐N‐butylcarbamates
G Lin, GH Chen, CP Lu, SC Yeh - QSAR & Combinatorial …, 2005 - Wiley Online Library
Acyloxy‐biphenyl‐4′‐N‐butylcarbamates (1–8) are synthesized from 4, 4′‐biphenol by
two‐step reactions. Carbamates 1–7 are characterized as the pseudo‐substrate inhibitors of …
two‐step reactions. Carbamates 1–7 are characterized as the pseudo‐substrate inhibitors of …
Probing the peripheral anionic site of acetylcholinesterase with quantitative structure activity relationships for inhibition by biphenyl‐4‐acyoxylate‐4′‐N …
G Lin, GH Chen, SC Yeh, CP Lu - Journal of Biochemical and …, 2005 - Wiley Online Library
Abstract Biphenyl‐4‐acyoxylate‐4′‐N‐butylcarbamates 1–8 are synthesized from 4, 4′‐
biphenol and are characterized as the pseudosubstrate inhibitors of acetylcholinesterase. In …
biphenol and are characterized as the pseudosubstrate inhibitors of acetylcholinesterase. In …