Lineage plasticity, the ability of cells to transition from one committed developmental
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …

Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest
human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises …

Intratumoral phenotypic heterogeneity has been described in many tumor types, where it
can contribute to drug resistance and disease recurrence. We analyzed ductal and …

Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest forms of cancer.
A major reason for this situation is the fact that these tumors are already resistant or become …

Long noncoding RNAs (lncRNAs) have been gradually confirmed to be tumor-associated
biological molecules in recent years. However, the clinical significances of most lncRNAs in …

Giardia intestinalis is an important single‐celled human pathogen. Interestingly, this
organism has two equal‐sized transcriptionally active nuclei, each considered diploid. By …

Despite considerable scientific progress, the burden of cancer in our society remains a
major public health problem. Tumorigenesis is recognized as a complex and multistep …

We recently proposed a new bioinformatic algorithm called OncoFinder for quantifying the
activation of intracellular signaling pathways. It was proved advantageous for minimizing …

Background SET and MYND domain-containing protein 2 (SMYD2-OE) plays an important
role in cancer development through methylating histone and non-histone proteins. However …

Abstract Background and Aims Microscopic colitis (MC) is the most frequent condition in
subjects undergoing ileocolonoscopy for chronic non-bloody diarrhea (CNBD) in Western …