Glutamate receptor-mediated excitatory neurotransmission plays a key role in neural
development, differentiation and synaptic plasticity. However, excessive stimulation of …

Major depression is a common, severe, chronic, and often life-threatening illness. There is a
growing appreciation that, far from being a disease with purely psychological manifestations …

There is growing evidence from neuroimaging and ostmortem studies that severe mood
disorders, which have traditionally been conceptualized as neurochemical disorders, are …

Huntington's disease (HD) is caused by a CAG repeat expansion in exon 1 of the HD gene
resulting in a long polyglutamine tract in the N‐terminus of the protein huntingtin. Patients …

Ampakines are drugs structurally derived from aniracetam that potentiate currents mediated
by AMPA type glutamate receptors. These drugs slow deactivation and attenuate …

The causes of neurodegenerative disorders are multiple, and for most of them a mechanistic
understanding is still lacking. However, neurodegenerative diseases such as Alzheimer …

Previous reports suggest that age-related lysosomal disturbances contribute to Alzheimer-
type accumulations of protein species, blockage of axonal/dendritic transport, and synaptic …

Multiple lines of evidence implicate lysosomes in a variety of pathogenic events that produce
neurodegeneration. Genetic mutations that cause specific enzyme deficiencies account for …

Spinocerebellar ataxia type 28 (SCA28) is a neurodegenerative disease caused by
mutations of the mitochondrial protease AFG3L2. The SCA28 mouse model, which is …

The endocannabinoid system has been suggested to elicit signals that defend against
several disease states including excitotoxic brain damage. Besides direct activation with …