DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Cancer cells undergo many different alterations during their transformation, including
genetic and epigenetic events. The controlled division of healthy cells can be impaired …

Background Diffusely infiltrative growth of human astrocytic gliomas is one of the major
obstacles to successful tumor therapy. Thorough insights into the molecules and pathways …

Abnormal methylation of secreted frizzled‑related proteins (SFRPs) has been observed in
various human cancer types. The loss of SFRP gene expression induces the activation of …

Epigenetic changes such as DNA methylation, histone modification, and loss of genome
imprinting play a crucial role in esophageal squamous cell carcinogenesis, along with …

Wnt signal pathway genes are known to be involved with cancer development. Here we
tested the hypothesis whether DNA methylation of genes part of the Wnt signaling pathway …

Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. It has
been reported that histone demethylases are involved in the carcinogenesis of certain types …

Wnt signaling is involved in the regulation of cancer stem cells (CSCs); however, the
molecular mechanism involved is still obscure. SFRP1, a Wnt inhibitor, is downregulated in …

Esophageal squamous cell carcinoma (ESCC) is highly resistant to chemoradiation therapy.
We aimed to examine whether Nutlin‐3, a molecule that suppresses murine double min 2 …

Despite advances in the perioperative management of esophagectomy, it is still a highly
invasive procedure for esophageal cancer and is associated with severe postoperative …