The highly variable response rates to immunotherapies underscore our limited knowledge
about how tumors can manipulate immune cells. Here the membrane topology of natural …

Chimeric antigen receptors (CARs) are fusion proteins with an extracellular antigen
recognition domain and numerous intracellular signaling domains that have been …

Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour
microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) …

The implementation of immune checkpoint inhibitors to the oncology clinic signified a new
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …

Here we report on the existence and functionality of the immune checkpoint signal
regulatory protein α (SIRPα) in NK cells and describe how it can be modulated for cell …

Background Melanoma is typically regarded as the most dangerous form of skin cancer.
Although surgical removal of in situ lesions can be used to effectively treat metastatic …

Natural killer (NK) cells are innate lymphoid cells endowed with cytolytic activity and a
capacity to secrete cytokines and chemokines. Several lines of evidence suggest that NK …

Natural killer (NK) cells are an emerging cancer cellular therapy and potent mediators of
antitumor immunity. Cytokine-induced memory-like (ML) NK cellular therapy is safe and …

The liver is an immunologically tolerant organ that is uniquely equipped to limit
hypersensitivity to food-derived antigens and bacterial products through the portal vein and …

Immune check point inhibitors (ICIs) have marked their existence in the field of cancer
immunotherapy. Their existence dates to 2011 when the first anti-cytotoxic T lymphocyte …