Aspergillus fumigatus is a model fungal pathogen and a common cause of infection in
individuals with the primary immunodeficiency chronic granulomatous disease (CGD) …

Developing an effective and safe recombinant vaccine requires microbe-specific antigens
combined with an adjuvant/delivery system to strengthen protective immunity. In this study …

Fungal infections remain a threat due to the lack of broad-spectrum fungal vaccines and
protective antigens. Recent studies showed that attenuated Blastomyces dermatitidis …

Clinical and animal studies of coccidioidomycosis have demonstrated that activated CD4+ T
lymphocytes are essential for protection against this fungal respiratory disease. We …

Candida spp. can cause severe and chronic mucocutaneous and systemic infections in
immunocompromised individuals. Protection from mucocutaneous candidiasis depends on …

CD4 T cells play important and non-redundant roles in protection against infection with
diverse fungi. Distinct CD4 T cell subsets can mediate protection against fungal disease …

Fungi are ubiquitous, eukaryotic organisms found throughout the environment. These
microorganisms exist as either saprophytes or parasites, with the former obtaining nutrients …

Coccidioidomycosis is a fungal infection caused by Coccidioides posadasii and
Coccidioides immitis. It is estimated that 150,000 new infections occur in the United States …

Vaccinologists strive to harness immunity at mucosal sites of pathogen entry. We studied
respiratory delivery of an attenuated vaccine against Blastomyces dermatitidis. We created a …

Background We set out to determine the magnitude of antigen-specific memory T helper cell
responses to Pseudomonas aeruginosa in healthy humans and patients with cystic fibrosis …