Visceral leishmaniasis (VL) is one of the most fatal and neglected tropical diseases caused
by Leishmania donovani (L. donovani). The applications of currently available …

Visceral leishmaniasis (VL) or kala-azar, the most severe form of the disease, is endemic in
more than eighty countries across the world. To date, there is no approved vaccine against …

Ubc13 is an ubiquitin E2 conjugating enzyme that participates with many different E3 ligases
to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory …

Leishmaniasis is a neglected infectious disease with clinical presentations ranging from
asymptomatic or mild symptoms to chronic infection and eventual death. The mechanisms of …

One of the main obstacles to most medication administrations (such as the vaccine
constructs) is the cellular membrane's inadequate permeability, which reduces their …

Tissue-resident memory (TRM) T cells are a unique subset of memory T cells that are critical
for the first line of defense against pathogens or antigens in peripheral non-lymphoid tissues …

Currently, there is no licensed vaccine to protect against human visceral leishmaniasis (VL),
a potentially fatal disease caused by infection with Leishmania parasites. In the current …

Leishmaniases are neglected diseases caused by infection with Leishmania parasites and
there are currently no prophylactic vaccines. In this study, we designed in silico a synthetic …

Secreted and surface-displayed carbohydrates are essential for virulence and viability of
many parasites, including for immune system evasion. We have identified the α-Gal …

Visceral leishmaniasis, caused by Leishmania (L.) donovani and L. infantum protozoan
parasites, can provoke overwhelming and protracted epidemics, with high case-fatality rates …