[HTML][HTML] Obesity and cardiometabolic risk factors: from childhood to adulthood

D Drozdz, J Alvarez-Pitti, M Wójcik, C Borghi… - Nutrients, 2021 - mdpi.com
Obesity has become a major epidemic in the 21st century. It increases the risk of
dyslipidemia, hypertension, and type 2 diabetes, which are known cardiometabolic risk …

Diet and depression: exploring the biological mechanisms of action

W Marx, M Lane, M Hockey, H Aslam, M Berk… - Molecular …, 2021 - nature.com
The field of nutritional psychiatry has generated observational and efficacy data supporting a
role for healthy dietary patterns in depression onset and symptom management. To guide …

[HTML][HTML] Childhood and adolescent obesity: a review

AR Kansra, S Lakkunarajah, MS Jay - Frontiers in pediatrics, 2021 - frontiersin.org
Obesity is a complex condition that interweaves biological, developmental, environmental,
behavioral, and genetic factors; it is a significant public health problem. The most common …

[HTML][HTML] An ethical framework for human embryology with embryo models

NC Rivron, AM Arias, MF Pera, N Moris, HI M'hamdi - Cell, 2023 - cell.com
A human embryo's legal definition and its entitlement to protection vary greatly worldwide.
Recently, human pluripotent stem cells have been used to form in vitro models of early …

The key role of epigenetics in human disease prevention and mitigation

AP Feinberg - New England Journal of Medicine, 2018 - Mass Medical Soc
Epigenetics in Disease Prevention and Mitigation Epigenetics is the regulation of gene
expression through alterations in DNA or associated factors (other than the DNA sequence) …

[HTML][HTML] Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics

D Li, Y Li, S Yang, J Lu, X Jin, M Wu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The prevalence of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes
mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), is a severe burden in human …

[HTML][HTML] Machine learning and clinical epigenetics: a review of challenges for diagnosis and classification

S Rauschert, K Raubenheimer, PE Melton… - Clinical epigenetics, 2020 - Springer
Background Machine learning is a sub-field of artificial intelligence, which utilises large data
sets to make predictions for future events. Although most algorithms used in machine …

Smoking and pregnancy: Epigenetics and developmental origins of the metabolic syndrome

JM Rogers - Birth defects research, 2019 - Wiley Online Library
Maternal smoking causes lower birth weight, birth defects, and other adverse pregnancy
outcomes. Epidemiological evidence over the past four decades has grown stronger and the …

The risk of offspring psychiatric disorders in the setting of maternal obesity and diabetes

L Kong, G Norstedt, M Schalling, M Gissler… - Pediatrics, 2018 - publications.aap.org
BACKGROUND: Prenatal exposure to metabolic disturbances is associated with increased
risk of offspring neurodevelopmental impairment and autism spectrum disorder, while little is …

[HTML][HTML] Exploring a complex interplay: kidney–gut axis in pediatric chronic kidney disease

A Mocanu, RA Bogos, TI Lazaruc, LM Trandafir… - Nutrients, 2023 - mdpi.com
The human intestinal microbiota is a highly intricate structure with a crucial role in promoting
health and preventing disease. It consists of diverse microbial communities that inhabit the …