Addictive drugs usurp the brain9s intrinsic mechanism for reward, leading to compulsive and
destructive behaviors. In the ventral tegmental area (VTA), the center of the brain9s reward …

The K+ channel interacting proteins (KChIPs) are a family of cytosolic proteins that interact
with Kv4 channels, leading to higher current density, modulation of channel inactivation and …

Kir3 channels control excitability in the nervous system and the heart. Their surface
expression is strictly regulated, but mechanisms responsible for channel removal from the …

The histoblot technique, a hybrid of immunohistochemistry and immunoblotting techniques,
has emerged as an attractive alternative to study the expression levels of proteins. This …

Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce signals from G
protein-coupled receptors (GPCRs) to effector ion channels and enzymes Gαo, a member of …

Noradrenergic (NAergic) A7 neurons that project axonal terminals to the dorsal horn of the
spinal cord to modulate nociceptive signaling are suggested to receive tonic inhibition from …

The signaling cascade comprising the 4‐aminobutyrate (B) receptor (GABABR), G protein
and the G protein‐gated K+ channel (GIRK) mediates neuronal inhibition in the brain …

Classically, GABAB receptors are thought to regulate neuronal excitability via G‐protein‐
coupled inwardly rectifying potassium (GIRK) channels. Recent data, however, indicate that …

GABA B receptors are expressed in neurons of the dopamine system where they
bidirectionally modulate activity and release of glutamate, GABA, and dopamine itself …

Recent proteomic and biochemical evidence indicates that cellular signaling is organized in
protein modules. G protein-coupled receptors (GPCRs) are privileged entry points for …