The cerebellar cortex is among the brain regions showing the highest expression levels of G-
protein-gated inwardly-rectifying potassium (GIRK/Kir3) channels. Despite their critical …

Recent proteomic and biochemical evidence indicates that cellular signaling is organized in
protein modules. G protein-coupled receptors (GPCRs) are privileged entry points for …

G-protein activated inwardly rectifying K+ channels (GIRKs) of the heterotetrameric
GIRK1/GIRK4 composition mediate IK+ ACh in atrium and are regulated by cAMP …

Abstract GABA B receptors (GABA B Rs) regulate the excitability of most neurons in the
central nervous system by modulating the activity of enzymes and ion channels. In the …

The 2TM domain family of K channels are also known as the inward-rectifier K channel
family. This family includes the strong inward-rectifier K channels (K ir 2. x) that are …

We previously identified a region on chromosome 1 that harbor quantitative trait loci (QTLs)
with large effects on alcohol withdrawal risk using both chronic and acute models in mice …

The role of Gβγ subunits in Kir3 channel gating is well characterized. Here, we have studied
the role of Gβγ dimers during their initial contact with Kir3 channels, prior to their insertion …

Within the classical eye-blink conditioning, Purkinje cells within the cerebellum are known to
suppress their tonic firing rates for a well defined time period in response to the conditional …

The histoblot (in situ immunoblotting) technique is a simple, reproducible, and sensitive
method for protein detection that allows both protein quantitation and analysis of tissue …

Alzheimer's disease (AD) is characterized by a reorganization of brain activity determining
network hyperexcitability and loss of synaptic plasticity. Precisely, a dysfunction in …