The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Liver cancer has the fourth highest mortality rate of all cancers worldwide, with
hepatocellular carcinoma (HCC) being the most prevalent subtype. Despite great advances …

CRISPR-Cas9 gene editing has emerged as a powerful therapeutic technology, but the lack
of safe and efficient in vivo delivery systems, especially for tissue-specific vectors, limits its …

Current computational workflows for comparative analyses of single-cell datasets typically
use discrete clusters as input when testing for differential abundance among experimental …

The treatment of low-risk primary prostate cancer entails active surveillance only, while high-
risk disease requires multimodal treatment including surgery, radiation therapy, and …

Lipid nanoparticles (LNPs) are the leading nonviral technologies for the delivery of
exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies …

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other …

Gut microbiota and the mammalian host share a symbiotic relationship, in which the host
provides a suitable ecosystem for the gut bacteria to digest indigestible nutrients and …

The porosity of liver sinusoidal endothelial cells (LSEC) ensures bidirectional passive
transport of lipoproteins, drugs and solutes between the liver capillaries and the liver …

Abstract Angiotensin-converting enzyme 2 (ACE2) is an important player of the renin-
angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II into …