Epithelial tissues function to protect the organism from physical, chemical, and microbial
damage and are essential for survival. To perform this role, epithelial keratinocytes undergo …

The pathogenesis of acne is complex, with strong evidence supporting the involvement of
sebaceous hyperplasia, follicular hyperkeratinisation, bacterial hypercolonisation, as well as …

Background: Skin laxity, rhytides, and photoaging are generally treated by ablative
procedures that injure or destroy the epidermis and its basement membrane, at least in the …

Background: Photoaging is generally treated by ablative procedures that injure the
epidermis and basal membrane and lead to fibrosis of the papillary dermis. Damaging the …

The term retinoid includes both natural and synthetic derivatives of vitamin A. Retinoid‐
containing treatments have been used since∼ 1550 BC by the early E gyptians. Treatment …

We have cloned a mouse cDNA homolog of P450RAI, a cytochrome P450 belonging to a
new family (CYP26), which has previously been isolated from zebrafish and human cDNAs …

Oncogenesis is closely linked to abnormalities in cell differentiation. Notch signaling
provides an important form of intercellular communication involved in cell fate determination …

Although the physiologic role of thyroid hormone in skin is not well understood, mounting
evidence suggests that T3 plays an important role in epidermal proliferation. The goal of this …

Self-renewing epithelia are characterized by a high turnover rate and a fine balance
between growth and differentiation. Such a balance is influenced by many exogenous …

Exposure to the environmental contaminant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)
results in a variety of pathological lesions in humans via activation of the aryl hydrocarbon …