Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

The distal lung provides an intricate structure for gas exchange in mammalian lungs.
Efficient gas exchange depends on the functional integrity of lung alveoli. The cells in the …

The decrease of microglia in the hippocampus is a novel mechanism for depression onset.
Reversal of this decrease can ameliorate stress-induced depression-like behaviors in …

Pathological studies have shown an association between psoriasis and renal injury (RI), but
the mechanism between RI and psoriasis was still unclear. This paper was designed to …

Platelet activation contributes to organs failure in inflammation and plays an important role in
endotoxemia. Clopidogrel inhibits platelet aggregation and activation. However, the role of …

Platelets possess three P2 receptors: two (P2Y 1 and P2Y 12) are receptors for ADP, and
one (P2X 1) is a receptor for ATP. P2Y 1, a Gq-coupled receptor, is responsible for …

Recent studies had reported that compounds that stimulate microglia could be developed as
potential drugs for the treatment of depression due to their reversal effect on depression-like …

Platelets are typically recognized for their roles in the maintenance of hemostasis and
vascular wall repair to reduce blood loss. Beyond hemostasis, platelets also play a critical …

Objective It's crucial to identify an easily detectable biomarker that is specific to radiation
injury in order to effectively classify injured individuals in the early stage in large-scale …

Objective (s): Immunomodulatory activity of β-glucans of shiitake mushroom (Lentinula
edodes) has been known. We investigated whether β-glucans from L. edodes would …