Traditionally, vaccines have helped eradication of several infectious diseases and also
saved millions of lives in the human history. Those prophylactic vaccines have acted through …

The use of particulate carriers holds great promise for the development of effective and
affordable recombinant vaccines. Rational development requires a detailed understanding …

Current vaccine development includes optimization of antigen delivery to antigen presenting
cells, such as dendritic cells (DC). Particulate systems have attracted increasing attention in …

Autologous dendritic cells transfected with total renal tumor RNA have been shown to be
potent stimulators of CTLs and antitumor immunity in vitro. A Phase I trial was conducted to …

Infection can protect against subsequent disease by induction of both humoral and cellular
immunity, but inert protein-based vaccines are not as effective. In this study, we present a …

We investigated the differentiation and trafficking of inflammatory monocytes that
phagocytosed subcutaneously injected fluorescent microspheres. As expected, most of the …

CD8+ T‐cell responses are critical in the immunological control of tumours and infectious
diseases. To prime CD8+ T cells against these cell‐associated antigens, exogenous …

Highlights•Dendritic cells internalize exogenous antigens for cross-presentation on MHC
I.•MHC I cross-presentation allows immune surveillance of viral infection and …

It was originally thought that a cell's major histocompatibility complex (MHC) class I
molecules presented peptides derived exclusively from proteins synthesized by the cell …

The adaptive immune system has evolved distinct responses against different pathogens,
but the mechanism (s) by which a particular response is initiated is poorly understood. In this …