Phytocannabinoids are bioactive natural products found in some flowering plants, liverworts,
and fungi that can be beneficial for the treatment of human ailments such as pain, anxiety …

The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Cannabinoid receptors, endocannabinoids and the enzymes responsible for their
biosynthesis and degradation constitute the endocannabinoid system. In recent decades …

Cannabidiol (CBD) is a major phytocannabinoid present in Cannabis sativa (Linneo, 1753).
This naturally occurring secondary metabolite does not induce intoxication or exhibit the …

The CB 1 and CB 2 cannabinoid receptors (CB 1 R, CB 2 R) are members of the G protein-
coupled receptor (GPCR) family that were identified over 20 years ago. CB 1 Rs and CB 2 …

Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …

Microglia, the resident immune cells of the central nervous system, mediate brain
homeostasis by controlling neuronal proliferation/differentiation and synaptic activity. In …

After alcohol and nicotine, marijuana is the most commonly used" recreational" drug in
Western countries. There has already been a growing debate about the medical …

Cannabis is an annual plant with a long history of use as food, feed, fiber, oil, medicine, and
narcotics. Despite realizing its true value, it has not yet found its true place. Cannabis has …

Abstract Cannabinoid CB2 receptors (CB2Rs) are expressed in mouse brain dopamine (DA)
neurons and are involved in several DA-related disorders. However, the cell type-specific …