Bioinspired oral delivery devices

X Zhang, G Chen, H Zhang, L Shang… - Nature Reviews …, 2023 - nature.com
Oral administration is a widespread and convenient drug delivery approach. However, oral
delivery can be affected by the complex digestive tract environment, including irregular …

Progress and prospects of polysaccharide-based nanocarriers for oral delivery of proteins/peptides

H Yuan, C Guo, L Liu, L Zhao, Y Zhang, T Yin… - Carbohydrate …, 2023 - Elsevier
The oral route has long been recognized as the most preferred route for drug delivery as it
offers high patient compliance and requires minimal expertise. Unlike small molecule drugs …

Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery

Z Sang, L Xu, R Ding, M Wang, X Yang, X Li… - Nature …, 2023 - nature.com
The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking
inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles …

Zwitterionic polymers: addressing the barriers for drug delivery

M Li, W Zhang, J Li, Y Qi, C Peng, N Wang, H Fan… - Chinese Chemical …, 2023 - Elsevier
Nanocarriers play an important role in drug delivery for disease treatment. However,
nanocarriers face a series of physiological barriers after administration such as blood …

Legume-derived bioactive peptides in type 2 diabetes: opportunities and challenges

K Hu, H Huang, H Li, Y Wei, C Yao - Nutrients, 2023 - mdpi.com
Diabetes mellitus is a complex disorder characterized by insufficient insulin production or
insulin resistance, which results in a lifelong dependence on glucose-lowering drugs for …

Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

C Chen, A Beloqui, Y Xu - Advanced drug delivery reviews, 2023 - Elsevier
Oral administration is the preferred route of administration based on the convenience for and
compliance of the patient. Oral nanomedicines have been developed to overcome the …

Is polydopamine beneficial for cells on the modified surface?

Y Yu, X Wang, Y Zhu, Y He, H Xue… - Regenerative …, 2022 - academic.oup.com
Since the pioneering work of Messersmith's group discovering that polydopamine (PDA) can
serve to adhere to many types of materials, the PDA coating has, as a biomimetic approach …

Challenges and opportunities in delivering oral peptides and proteins

H Peng, J Wang, J Chen, Y Peng, X Wang… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Rapid advances in bioengineering enable the use of complex proteins as
therapeutic agents to treat diseases. Compared with conventional small molecule drugs …

Advances in surface-modified nanometal-organic frameworks for drug delivery

J Li, H Peng, W Ji, D Lu, N Wang, C Peng… - International Journal of …, 2023 - Elsevier
Nanometal-organic frameworks (NMOFs) are porous network structures composed of metal
ions or metal clusters through self-assembly. NMOFs have been considered as a promising …

Fat fighting liraglutide based nano-formulation to reverse obesity: design, development and animal trials

DK Jakhar, VK Vishwakarma, R Singh, K Jadhav… - International Journal of …, 2023 - Elsevier
Obesity is a metabolic disease, which is one of the major causes of morbidity and mortality,
where therapeutic options are limited. Treatment of obesity is necessary as it is associated …