Status of PSMA-targeted radioligand therapy in prostate cancer: current data and future trials

A Jang, AT Kendi, O Sartor - Therapeutic Advances in …, 2023 - journals.sagepub.com
Metastatic prostate cancer continues to be an incurable disease. Despite all the novel
therapies approved in the past two decades, overall patient outcomes remain relatively poor …

[HTML][HTML] ImmunoPET: antibody-based PET imaging in solid tumors

R Manafi-Farid, B Ataeinia, S Ranjbar… - Frontiers in …, 2022 - frontiersin.org
Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

Predictors and real-world use of prostate-specific radioligand therapy: PSMA and beyond

A Gafita, C Marcus, L Kostos, DM Schuster… - American Society of …, 2022 - ascopubs.org
PSMA is a transmembrane protein that is markedly overexpressed in prostate cancer,
making it an excellent target for imaging and treating patients with prostate cancer. Several …

[HTML][HTML] Pharmacological optimization of PSMA-based radioligand therapy

S van der Gaag, IH Bartelink, AN Vis, GL Burchell… - Biomedicines, 2022 - mdpi.com
Prostate cancer (PCa) is the most common malignancy in men of middle and older age. The
standard treatment strategy for PCa ranges from active surveillance in low-grade, localized …

177Lu-PSMA-I&T for treatment of metastatic castration-resistant prostate cancer: prognostic value of scintigraphic and clinical biomarkers

A Karimzadeh, M Heck, R Tauber, K Knorr… - Journal of Nuclear …, 2023 - Soc Nuclear Med
The aim of this retrospective analysis was to determine prostate-specific antigen (PSA)
response, PSA progression-free survival (PFS), and overall survival (OS) in a large cohort of …

Determinants of outcome following PSMA-based radioligand therapy and mechanisms of resistance in patients with metastatic castration-resistant prostate cancer

L Kostos, JP Buteau, MS Hofman… - … Advances in Medical …, 2023 - journals.sagepub.com
[177Lu] Lu-PSMA has recently been approved for use in the post-taxane, post-novel
hormonal-agent setting in patients with metastatic castration-resistant prostate cancer. As a …

[177Lu] Lu-PSMA-radioligand therapy efficacy outcomes in taxane-naïve versus taxane-treated patients with metastatic castration-resistant prostate cancer: a …

S Satapathy, RK Sahoo, C Bal - Journal of Nuclear Medicine, 2023 - Soc Nuclear Med
Radioligand therapy (RLT) with 177Lu-prostate-specific membrane antigen (PSMA)
inhibitors ([177Lu] Lu-PSMA) is currently approved for patients with metastatic castration …

[HTML][HTML] Individual radiosensitivity reflected by γ-H2AX and 53BP1 foci predicts outcome in PSMA-targeted radioligand therapy

L Widjaja, RA Werner, E Krischke… - European Journal of …, 2023 - Springer
Purpose γ-H2AX and 53BP1 are fundamental for cellular DNA damage response (DDR)
after radiation exposure and are linked to cell repair, arrest, or apoptosis. We aimed to …

Novel radionuclide therapy combinations in prostate cancer

AJ Inderjeeth, A Iravani… - Therapeutic …, 2023 - journals.sagepub.com
Prostate cancer remains the commonest cancer diagnosed in males and a leading cause of
cancer-related death. Men with metastatic castration-resistant prostate cancer (mCRPC) …

[HTML][HTML] Predictive and prognostic potential of pretreatment 68Ga-PSMA PET tumor heterogeneity index in patients with metastatic castration-resistant prostate cancer …

M Assadi, R Manafi-Farid, E Jafari, A Keshavarz… - Frontiers in …, 2022 - frontiersin.org
Introduction This study was conducted to evaluate the predictive values of volumetric
parameters and radiomic features (RFs) extracted from pretreatment 68Ga-PSMA PET and …