Status of PSMA-targeted radioligand therapy in prostate cancer: current data and future trials
Metastatic prostate cancer continues to be an incurable disease. Despite all the novel
therapies approved in the past two decades, overall patient outcomes remain relatively poor …
therapies approved in the past two decades, overall patient outcomes remain relatively poor …
[HTML][HTML] ImmunoPET: antibody-based PET imaging in solid tumors
Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …
combining the high sensitivity of PET with the specific targeting ability of monoclonal …
Predictors and real-world use of prostate-specific radioligand therapy: PSMA and beyond
PSMA is a transmembrane protein that is markedly overexpressed in prostate cancer,
making it an excellent target for imaging and treating patients with prostate cancer. Several …
making it an excellent target for imaging and treating patients with prostate cancer. Several …
[HTML][HTML] Pharmacological optimization of PSMA-based radioligand therapy
S van der Gaag, IH Bartelink, AN Vis, GL Burchell… - Biomedicines, 2022 - mdpi.com
Prostate cancer (PCa) is the most common malignancy in men of middle and older age. The
standard treatment strategy for PCa ranges from active surveillance in low-grade, localized …
standard treatment strategy for PCa ranges from active surveillance in low-grade, localized …
177Lu-PSMA-I&T for treatment of metastatic castration-resistant prostate cancer: prognostic value of scintigraphic and clinical biomarkers
A Karimzadeh, M Heck, R Tauber, K Knorr… - Journal of Nuclear …, 2023 - Soc Nuclear Med
The aim of this retrospective analysis was to determine prostate-specific antigen (PSA)
response, PSA progression-free survival (PFS), and overall survival (OS) in a large cohort of …
response, PSA progression-free survival (PFS), and overall survival (OS) in a large cohort of …
Determinants of outcome following PSMA-based radioligand therapy and mechanisms of resistance in patients with metastatic castration-resistant prostate cancer
[177Lu] Lu-PSMA has recently been approved for use in the post-taxane, post-novel
hormonal-agent setting in patients with metastatic castration-resistant prostate cancer. As a …
hormonal-agent setting in patients with metastatic castration-resistant prostate cancer. As a …
[177Lu] Lu-PSMA-radioligand therapy efficacy outcomes in taxane-naïve versus taxane-treated patients with metastatic castration-resistant prostate cancer: a …
S Satapathy, RK Sahoo, C Bal - Journal of Nuclear Medicine, 2023 - Soc Nuclear Med
Radioligand therapy (RLT) with 177Lu-prostate-specific membrane antigen (PSMA)
inhibitors ([177Lu] Lu-PSMA) is currently approved for patients with metastatic castration …
inhibitors ([177Lu] Lu-PSMA) is currently approved for patients with metastatic castration …
[HTML][HTML] Individual radiosensitivity reflected by γ-H2AX and 53BP1 foci predicts outcome in PSMA-targeted radioligand therapy
L Widjaja, RA Werner, E Krischke… - European Journal of …, 2023 - Springer
Purpose γ-H2AX and 53BP1 are fundamental for cellular DNA damage response (DDR)
after radiation exposure and are linked to cell repair, arrest, or apoptosis. We aimed to …
after radiation exposure and are linked to cell repair, arrest, or apoptosis. We aimed to …
Novel radionuclide therapy combinations in prostate cancer
AJ Inderjeeth, A Iravani… - Therapeutic …, 2023 - journals.sagepub.com
Prostate cancer remains the commonest cancer diagnosed in males and a leading cause of
cancer-related death. Men with metastatic castration-resistant prostate cancer (mCRPC) …
cancer-related death. Men with metastatic castration-resistant prostate cancer (mCRPC) …
[HTML][HTML] Predictive and prognostic potential of pretreatment 68Ga-PSMA PET tumor heterogeneity index in patients with metastatic castration-resistant prostate cancer …
Introduction This study was conducted to evaluate the predictive values of volumetric
parameters and radiomic features (RFs) extracted from pretreatment 68Ga-PSMA PET and …
parameters and radiomic features (RFs) extracted from pretreatment 68Ga-PSMA PET and …