Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM) that
disrupts and replaces functional parenchyma, which leads to organ failure. It is known as the …

Epigenetic mechanisms control gene expression during normal development and their
aberrant regulation may lead to human diseases including cancer. Natural phytochemicals …

DNA methylation is a covalent chemical modification of DNA catalyzed by DNA
methyltransferases (DNMTs). DNA methylation is associated with transcriptional silencing …

Epigenetics plays an important role in orchestrating key biologic processes. Epigenetic
marks, including DNA methylation, histones, chromatin structure, and noncoding RNAs, are …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human
malignancy in the world, with high mortality and poor prognosis for patients. Among the risk …

Chronic exposures to heavy metals via tobacco smoking and professional exposure may
increase the risk of head and neck cancer, although the epidemiologic evidence is limited by …

Obesity is associated with increased classically activated M1 adipose tissue macrophages
(ATMs) and decreased alternatively activated M2 ATMs, both of which contribute to obesity …

The PI3-kinase/AKT pathway integrates signals from external cellular stimuli to regulate
essential cellular functions, and is frequently aberrantly activated in human cancers. Recent …

Adipose tissue macrophages (ATMs) undergo a phenotypic switch from alternatively
activated antiinflammatory M2 macrophages in lean individuals to classically activated …

Background DNA hypermethylation events and other epimutations occur in many
neoplasms, producing gene expression changes that contribute to neoplastic …