Nutraceutical boom in cancer: inside the labyrinth of reactive oxygen species

M Calvani, A Pasha, C Favre - International journal of molecular sciences, 2020 - mdpi.com
In recent years, epidemiological studies have shown that food is a very powerful means for
maintaining a state of well-being and for health prevention. Many degenerative, autoimmune …

Inhibiting DNA methylation by 5-Aza-2′-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation

Q Cao, X Wang, L Jia, AK Mondal, A Diallo… - …, 2014 - academic.oup.com
Inflammation marks all stages of atherogenesis. DNA hypermethylation in the whole
genome or specific genes is associated with inflammation and cardiovascular diseases …

Anticancer effects of lactoferrin: Underlying mechanisms and future trends in cancer therapy

Y Zhang, CF Lima, LR Rodrigues - Nutrition reviews, 2014 - academic.oup.com
Lactoferrin has been widely studied over the last 70 years, and its role in diverse biological
functions is now well known and generally accepted by the scientific community. Usually …

Dietary intervention modifies DNA methylation age assessed by the epigenetic clock

C Sae‐Lee, S Corsi, TM Barrow… - Molecular nutrition & …, 2018 - Wiley Online Library
Scope Alterations in DNA methylation patterns are correlated with aging, environmental
exposures, and disease pathophysiology; the possibility of reverting or preventing these …

DNMT1-PPARγ pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice

J Yu, Y Qiu, J Yang, S Bian, G Chen, M Deng, H Kang… - Scientific reports, 2016 - nature.com
The DNA methyltransferase-mediated proinflammatory activation of macrophages is
causally linked to the development of atherosclerosis (AS). However, the role of DNMT1, a …

Detection of colorectal cancer in urine using DNA methylation analysis

S Bach, I Paulis, NR Sluiter, M Tibbesma, I Martin… - Scientific reports, 2021 - nature.com
Colorectal cancer (CRC) is the second leading cause for cancer-related death globally.
Clinically, there is an urgent need for non-invasive CRC detection. This study assessed the …

Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment

AM Dworkin, THM Huang, AE Toland - Seminars in cancer biology, 2009 - Elsevier
Epigenetic alterations of the genome such as DNA promoter methylation and chromatin
remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic …

Effect of aberrant DNA methylation on cancer stem cell properties

Z Mazloumi, R Farahzadi, A Rafat, KD Asl… - Experimental and …, 2022 - Elsevier
DNA methylation, as an epigenetic mechanism, occurs by adding a methyl group of
cytosines in position 5 by DNA methyltransferases and has essential roles in cellular …

[HTML][HTML] Novel epigenetic therapeutic strategies and targets in cancer

Q Babar, A Saeed, TA Tabish, S Pricl, H Townley… - … et Biophysica Acta (BBA …, 2022 - Elsevier
The critical role of dysregulated epigenetic pathways in cancer genesis, development, and
therapy has typically been established as a result of scientific and technical innovations in …

Aberrant DNA and RNA methylation occur in spinal cord and skeletal muscle of human SOD1 mouse models of ALS and in human ALS: targeting DNA methylation is …

LJ Martin, DA Adams, MV Niedzwiecki, M Wong - Cells, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal disease. Skeletal muscles and motor neurons
(MNs) degenerate. ALS is a complex disease involving many genes in multiple tissues, the …