In this study we investigated the effects of maternal deprivation on adult rats' spatial learning
and memory, exploratory, and limbic activity and their correlations with the gene expression …

In addition to genetic mutations, epigenetic revision plays a major role in the development
and progression of cancer; specifically, inappropriate DNA methylation or demethylation of …

Regucalcin is a unique calcium-binding protein first discovered in rat liver in 1978.
Regucalcin has multiple functions as an inhibitor of various cellular signaling pathways that …

DNA methylation is considered to play an essential role in cellular senescence. To uncover
the mechanism underlying cellular senescence, we established the model of premature …

The secretions of cancer cells alter epigenetic regulation in cancer stromal cells. The
present study investigated the methylation changes in white blood cells (WBCs) caused by …

The dominant pathogenic model, somatic mutation theory (SMT), considers carcinogenesis
as a 'genetic accident'due to the accumulation of 'stochastic'DNA mutations. This model was …

Background: Major depression has a complex and multifactorial etiology constituted by the
interaction between genetic and environmental factors in its development. Objective: The …

Tamoxifen is a standard anti‐hormone treatment in estrogen receptor positive breast
carcinoma patients. Unfortunately, about 50% of patients relapse during treatment. Promoter …

Background Colorectal cancer (CRC) is one of the most common and comprehensively
studied malignancies. Hypoxic conditions during formation of CRC may support the …

Barrett's esophagus, a pre-malignant condition that can lead to esophageal
adenocarcinoma, is characterized by histological changes in the normal squamous …