Type 2 immunity in the skin and lungs

CA Akdis, PD Arkwright, MC Brüggen, W Busse… - Allergy, 2020 - Wiley Online Library
There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

Mast cells as sources of cytokines, chemokines, and growth factors

K Mukai, M Tsai, H Saito, SJ Galli - Immunological reviews, 2018 - Wiley Online Library
Mast cells are hematopoietic cells that reside in virtually all vascularized tissues and that
represent potential sources of a wide variety of biologically active secreted products …

[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis

M Steinhoff, F Ahmad, A Pandey, A Datsi… - Journal of Allergy and …, 2022 - Elsevier
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

Proteolytic processing of interleukin-1 family cytokines: variations on a common theme

IS Afonina, C Müller, SJ Martin, R Beyaert - Immunity, 2015 - cell.com
Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and
IL-36, play a pivotal role in the initiation and amplification of immune responses. However …

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

E Lefrançais, S Roga, V Gautier… - Proceedings of the …, 2012 - National Acad Sciences
Interleukin-33 (IL-33)(NF-HEV) is a chromatin-associated nuclear cytokine from the IL-1
family, which has been linked to important diseases, including asthma, rheumatoid arthritis …

Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33 …

M Pichery, E Mirey, P Mercier, E Lefrancais… - The Journal of …, 2012 - journals.aai.org
IL-33 (previously known as NF from high endothelial venules) is an IL-1 family cytokine that
signals through the ST2 receptor and drives cytokine production in mast cells, basophils …

The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB–stimulated gene transcription

S Ali, A Mohs, M Thomas, J Klare, R Ross… - The Journal of …, 2011 - journals.aai.org
Full-length IL-33 is a member of the IL-1 family of cytokines, which can act in an autocrine or
paracrine manner by binding to the IL-33R on several different target cell types. In addition …

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

S Makaremi, A Asgarzadeh, H Kianfar… - Inflammation …, 2022 - Springer
A global pandemic has erupted as a result of the new brand coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated …

[HTML][HTML] Innate lymphoid cells in allergic and nonallergic inflammation

H Morita, K Moro, S Koyasu - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
In the last decade, the full picture of the role of innate lymphoid cells (ILCs) has been
gradually revealed. ILCs are classified into 3 groups based on their transcription factors and …

IL-33 is an unconventional Alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells

BM Matta, JM Lott, LR Mathews, Q Liu… - The Journal of …, 2014 - journals.aai.org
IL-33 is a recently characterized IL-1 family member that is proposed to function as an
alarmin, or endogenous signal of cellular damage, as well as act as a pleiotropic cytokine …