Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology

DG Cabalo, J DeKraker, J Royer, K Xie, S Tavakol… - Brain, 2024 - academic.oup.com
Declarative memory encompasses episodic and semantic divisions. Episodic memory
captures singular events with specific spatiotemporal relationships, whereas semantic …

Pharmaco-resistant temporal lobe epilepsy gradually perturbs the cortex-wide excitation-inhibition balance

K Xie, J Royer, R Rodriguez-Cruces, L Horwood… - bioRxiv, 2024 - biorxiv.org
Excitation-inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology
of epilepsy, with a mounting body of previous research focusing on elucidating its cellular …

HippoMaps: Multiscale cartography of human hippocampal organization

J DeKraker, DG Cabalo, J Royer, AR Khan, B Karat… - bioRxiv, 2024 - biorxiv.org
The hippocampus has a unique microarchitecture, is situated at the nexus of multiple
macroscale functional networks, contributes to numerous cognitive as well as affective …

Differential relational memory impairment in temporal lobe epilepsy

S Tavakol, V Kebets, J Royer, Q Li, H Auer… - Epilepsy & Behavior, 2024 - Elsevier
Objective Temporal lobe epilepsy (TLE) is typically associated with pathology of the
hippocampus, a key structure involved in relational memory, including episodic, semantic …

[HTML][HTML] Abnormal Weakening of DNA Methylation around the SLC6A1 Gene Promoter in Temporal Lobe Epilepsy

H Tao, Z Wu, Y Liu, X Zhang, K Li… - Journal of Integrative …, 2024 - imrpress.com
Background: The solute carrier (SLC) superfamily, which transports solutes across biological
membranes, includes four members (SLC2A1, SLC6A1, SLC9A64, and SLC35A2) that have …

Microangiopathy in temporal lobe epilepsy with diffusion MRI alterations and cognitive decline

J Liu, L Binding, I Puntambekar, S Patodia, Y Lim… - 2024 - researchsquare.com
White matter microvascular alterations in temporal lobe epilepsy (TLE) can influence local
hemodynamics and are relevant to understanding acquired neurodegenerative processes …