Background The poor physical health of people with mental illness is a multifaceted,
transdiagnostic, and global problem. People with mental illness have an increased risk of …

Individuals diagnosed with schizophrenia or bipolar disorder have a life expectancy 15–20
years shorter than that in the general population. The rate of unnatural deaths, such as …

The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …

Introduction Physical activity, conceptualized as any bodily movement that results in energy
expenditure, and its structured form, exercise, play an important role in public health …

The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia seeks to reduce these substantial psychosocial and public health …

Background Exercise may improve neuropsychiatric and cognitive symptoms in people with
mental disorders, but the totality of the evidence is unclear. We conducted a meta-review of …

People with serious mental illness (SMI), including schizophrenia, bipolar disorder, and
major depressive disorder, have a higher mortality rate and shortened life expectancy. This …

Treatment-resistant schizophrenia (TRS) represents a major clinical challenge. The broad
definition of TRS requires nonresponse to at least 2 sequential antipsychotic trials of …

Mood disorders and type 2 diabetes mellitus (T2DM) are prevalent conditions that often co-
occur. We reviewed the available evidence from longitudinal and Mendelian randomisation …

Importance Schizophrenia is associated with cognitive dysfunction and cardiovascular risk
factors, including metabolic syndrome (MetS) and its constituent criteria. Cognitive …