Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global
health care priority. Some analyses, including the O'Neill report, have predicted that deaths …

Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …

Fungal pathogens pose a global threat to human health, with Candida albicans among the
leading killers. Systematic analysis of essential genes provides a powerful strategy to …

Cell-cycle checkpoints and DNA repair processes protect organisms from potentially lethal
mutational damage. Compared to other budding yeasts in the subphylum …

Cellular quiescence, the temporary and reversible exit from proliferative growth, is the
predominant state of all cells. However, our understanding of the biological processes and …

We recently reported transposon mutagenesis as a significant driver of spontaneous
mutations in the human fungal pathogen Cryptococcus deneoformans during murine …

Copy number variants (CNVs), duplications and deletions of genomic sequences, contribute
to evolutionary adaptation but can also confer deleterious effects and cause disease …

Fungal pathogens represent a major human threat affecting more than a billion people
worldwide. Invasive infections are on the rise, which is of considerable concern because …

Invasive fungal infections (IFIs) pose a serious clinical problem, but the antifungal arsenal is
limited and has many disadvantages, such as drug resistance and toxicity. Hence, there is …

Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However,
FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making …