Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with
global inhibitors of TGF-β have been disappointing, suggesting that a more targeted …

Obesity represents a major risk factor for a plethora of severe diseases, including diabetes,
cardiovascular disease, non-alcoholic fatty liver disease, and cancer. It is often …

Background The principal biological processes that characterize heart failure with a
preserved ejection fraction (HFpEF) are systemic inflammation, epicardial adipose tissue …

Background The prevalence of class III obesity (body mass index [BMI]≥ 40 kg/m2) has
increased dramatically in several countries and currently affects 6% of adults in the US, with …

Turmeric (Curcuma longa), a rhizomatous herbaceous perennial plant of the ginger family,
has been used for the treatment of diabetes in Ayurvedic and traditional Chinese medicine …

Background Ancestral environmental exposures to a variety of environmental factors and
toxicants have been shown to promote the epigenetic transgenerational inheritance of adult …

Identification of sequence variants robustly associated with predisposition to diabetic kidney
disease (DKD) has the potential to provide insights into the pathophysiological mechanisms …

Chronic kidney disease (CKD) is prevalent in 9.1% of the global population and is a
significant public health problem associated with increased morbidity and mortality. CKD is …

Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …

摘要背景本研究旨在探讨亚洲2 型糖尿病患者中慢性肾病与肥胖和体重改变的相关性.
方法基线研究在2003–2005 年招募1187 位年龄30–70 岁的2 型糖尿病患者, 并在2008, 2009 …