Advances in the development of influenza virus vaccines
F Krammer, P Palese - Nature reviews Drug discovery, 2015 - nature.com
Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …
Tackling influenza with broadly neutralizing antibodies
D Corti, E Cameroni, B Guarino, NL Kallewaard… - Current opinion in …, 2017 - Elsevier
Highlights•Broadly neutralizing antibodies against influenza A and B represents a safe and
affordable alternative to convalescent plasma.•The large majority of broadly neutralizing …
affordable alternative to convalescent plasma.•The large majority of broadly neutralizing …
Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus
The generation of strain-specific neutralizing antibodies against influenza A virus is known
to confer potent protection against homologous infections. The majority of these antibodies …
to confer potent protection against homologous infections. The majority of these antibodies …
Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans
AH Ellebedy, F Krammer, GM Li… - Proceedings of the …, 2014 - National Acad Sciences
The emergence of pandemic influenza viruses poses a major public health threat. Therefore,
there is a need for a vaccine that can induce broadly cross-reactive antibodies that protect …
there is a need for a vaccine that can induce broadly cross-reactive antibodies that protect …
IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity
Y Avnir, CT Watson, J Glanville, EC Peterson… - Scientific reports, 2016 - nature.com
IGHV polymorphism provides a rich source of humoral immune system diversity. One
important example is the IGHV1-69 germline gene where the biased use of alleles that …
important example is the IGHV1-69 germline gene where the biased use of alleles that …
Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins
R Nachbagauer, A Choi, A Hirsh, I Margine, S Iida… - Nature …, 2017 - nature.com
Infection with influenza virus induces antibodies to the viral surface glycoproteins
hemagglutinin and neuraminidase, and these responses can be broadly protective. To …
hemagglutinin and neuraminidase, and these responses can be broadly protective. To …
[HTML][HTML] In the shadow of hemagglutinin: a growing interest in influenza viral neuraminidase and its role as a vaccine antigen
TJ Wohlbold, F Krammer - Viruses, 2014 - mdpi.com
Despite the availability of vaccine prophylaxis and antiviral therapeutics, the influenza virus
continues to have a significant, annual impact on the morbidity and mortality of human …
continues to have a significant, annual impact on the morbidity and mortality of human …
Induction of broadly reactive anti-hemagglutinin stalk antibodies by an H5N1 vaccine in humans
R Nachbagauer, TJ Wohlbold, A Hirsh, R Hai… - Journal of …, 2014 - Am Soc Microbiol
Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current vaccines are effective but strain specific due to their focus …
and mortality worldwide. Current vaccines are effective but strain specific due to their focus …
Age dependence and isotype specificity of influenza virus hemagglutinin stalk-reactive antibodies in humans
R Nachbagauer, A Choi, R Izikson, MM Cox, P Palese… - MBio, 2016 - Am Soc Microbiol
Influenza remains a major global health burden. Seasonal vaccines offer protection but can
be rendered less effective when the virus undergoes extensive antigenic drift. Antibodies …
be rendered less effective when the virus undergoes extensive antigenic drift. Antibodies …
Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses
PH Goff, T Hayashi, L Martínez-Gil, M Corr… - Journal of …, 2015 - Am Soc Microbiol
Current vaccines against influenza virus infection rely on the induction of neutralizing
antibodies targeting the globular head of the viral hemagglutinin (HA). Protection against …
antibodies targeting the globular head of the viral hemagglutinin (HA). Protection against …