Propofol: an update of its use in anaesthesia and conscious sedation
HM Bryson, BR Fulton, D Faulds - Drugs, 1995 - Springer
Synopsis Propofol is an intravenous sedative hypnotic agent which rapidly and reliably
causes loss of consciousness. It is also associated with a quick and 'smooth'recovery, which …
causes loss of consciousness. It is also associated with a quick and 'smooth'recovery, which …
Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature
A Roussin, JL Montastruc… - Fundamental & clinical …, 2007 - Wiley Online Library
Abstract Propofol (2, 6‐diisopropylphenol) is an intravenous short‐acting anaesthetic widely
used for inducing and maintaining anaesthesia. Propofol is also being increasingly used for …
used for inducing and maintaining anaesthesia. Propofol is also being increasingly used for …
Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter
XN Zhu, J Li, GL Qiu, L Wang, C Lu, YG Guo, KX Yang… - Neuron, 2023 - cell.com
Lasker's award-winning drug propofol is widely used in general anesthesia. The
recreational use of propofol is reported to produce a well-rested feeling and euphoric state; …
recreational use of propofol is reported to produce a well-rested feeling and euphoric state; …
A survey of propofol abuse in academic anesthesia programs
PE Wischmeyer, BR Johnson, JE Wilson… - Anesthesia & …, 2007 - journals.lww.com
BACKGROUND: Although propofol has not traditionally been considered a drug of abuse,
subanesthetic doses may have an abuse potential. We used this survey to assess …
subanesthetic doses may have an abuse potential. We used this survey to assess …
In vivo dopamine measurements in the nucleus accumbens after nonanesthetic and anesthetic doses of propofol in rats
L Pain, S Gobaille, C Schleef, D Aunis… - Anesthesia & …, 2002 - journals.lww.com
There is growing evidence that propofol acts on affective and reward processes. We
designed this study to assess the effect of propofol on the concentration of dopamine in the …
designed this study to assess the effect of propofol on the concentration of dopamine in the …
A review of human drug self-administration procedures
JD Jones, SD Comer - Behavioural pharmacology, 2013 - journals.lww.com
Drug self-administration procedures in laboratory settings allow us to closely model drug-
taking behavior in real-world settings. This review provides an overview of many of the …
taking behavior in real-world settings. This review provides an overview of many of the …
Propofol sedation during gastrointestinal endoscopy arouses euphoria in a large subset of patients
T Brechmann, C Maier, M Kaisler… - United European …, 2018 - journals.sagepub.com
Background Propofol is recommended for sedation in gastrointestinal endoscopy (GE), but
preliminary data suggest addictive potentials. Objective The objective of this article is to …
preliminary data suggest addictive potentials. Objective The objective of this article is to …
Dreams, images and emotions associated with propofol anaesthesia
B Brandner, M Blagrove, G McCallum… - Anaesthesia, 1997 - Wiley Online Library
One hundred and twelve patients scheduled for day case varicose vein surgery were
randomly allocated to one of three groups: total intravenous anaesthesia with propofol …
randomly allocated to one of three groups: total intravenous anaesthesia with propofol …
LC–MS/MS and GC–MS methods in propofol detection: Evaluation of the two analytical procedures
F Vaiano, G Serpelloni, M Focardi, A Fioravanti… - Forensic science …, 2015 - Elsevier
Propofol is a short-acting hypnotic agent that is commonly used to induce and maintain
anesthesia. Propofol abuse and its involvement in suicide deaths have increased in recent …
anesthesia. Propofol abuse and its involvement in suicide deaths have increased in recent …
The effects of midazolam on propofol-induced anesthesia: propofol dose requirements, mood profiles, and perioperative dreams
DC Oxorn, LE Ferris, E Harrington… - Anesthesia & …, 1997 - journals.lww.com
This study examined the effects of midazolam on the doses of propofol required for the
induction of hypnosis and the maintenance of propofol/nitrous oxide anesthesia. In addition …
induction of hypnosis and the maintenance of propofol/nitrous oxide anesthesia. In addition …