Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

This review examines the relation between the mode of delivery and development of the
immune system in the offspring. Recent epidemiological studies provide evidence that …

DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …

We describe the direct detection of DNA methylation, without bisulfite conversion, through
single-molecule, real-time (SMRT) sequencing. In SMRT sequencing, DNA polymerases …

Environmental constraints during early life result in phenotypic changes that can be
associated with increased disease risk in later life. This suggests persistent alteration of …

The period of in utero development is one of the most critical windows during which adverse
intrauterine conditions and exposures can influence the growth and development of the …

The three-way connection between DNA methylation, gene activity and chromatin structure
has been known for almost two decades. Nevertheless, the molecular link between methyl …

The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …

Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of
epigenetic influence on human traits and disease. In addition to influences of age and …

The biological significance of interactions of nuclear proteins with DNA in the context of
gene expression, cell differentiation, or disease has immensely been enhanced by the …