Human variability in influx and efflux transporters in relation to uncertainty factors for chemical risk assessment
K Darney, L Turco, FM Buratti, E Di Consiglio… - Food and Chemical …, 2020 - Elsevier
Transporters are divided into the ABC and SLC super-families, mediating the cellular efflux
and influx of various xenobiotic and endogenous substrates. Here, an extensive literature …
and influx of various xenobiotic and endogenous substrates. Here, an extensive literature …
Genetic variability and haplotype profile of MDR1 (ABCB1) in Roma and Hungarian population samples with a review of the literature
The genetic variability, haplotype profile and ethnic differences of MDR1 polymorphisms in
healthy Roma and Hungarian populations were analyzed and the results were compared …
healthy Roma and Hungarian populations were analyzed and the results were compared …
Frequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population
M Milojkovic, S Stojnev, I Jovanovic… - Pharmacological …, 2011 - Springer
The multi-drug resistance 1 (MDR1) gene encodes for a P-glycoprotein (PGP), which acts as
a gate-keeper against various kinds of xenobiotics. Several single nucleotide …
a gate-keeper against various kinds of xenobiotics. Several single nucleotide …
Inter and intra-ethnic differences in the distribution of the molecular variants of TPMT, UGT1A1 and MDR1 genes in the South Indian population
G Umamaheswaran, D Krishna Kumar… - Molecular biology …, 2012 - Springer
Molecular variants of polymorphic drug metabolizing enzymes and drug transporters are
attributed to differences in individual's therapeutic response and drug toxicity in different …
attributed to differences in individual's therapeutic response and drug toxicity in different …
Pharmacogenetics in Central American healthy volunteers: interethnic variability
C Céspedes-Garro, MEG Naranjo… - Drug Metabolism and …, 2015 - degruyter.com
Ethnicity is one of the major factors involved in interindividual variability to drug response.
This study aims to describe the frequency of the most relevant pharmacogenetic biomarkers …
This study aims to describe the frequency of the most relevant pharmacogenetic biomarkers …
Genotype Variability and Haplotype Frequency of MDR1 (ABCB1) Gene Polymorphism in Morocco
Y Kassogue, H Dehbi, S Nassereddine… - DNA and Cell …, 2013 - liebertpub.com
The multidrug resistance gene (MDR1) plays an important role in the transport of a wide
range of drugs and elimination of xenobiotics from the body. Identification of polymorphisms …
range of drugs and elimination of xenobiotics from the body. Identification of polymorphisms …
Pharmacogenetic research activity in Central America and the Caribbean: a systematic review
C Cespedes-Garro, MEG Naranjo… - …, 2016 - Future Medicine
Aim: The present review was aimed at analyzing the pharmacogenetic scientific activity in
Central America and the Caribbean. Materials & methods: A literature search for …
Central America and the Caribbean. Materials & methods: A literature search for …
Genotype variability and haplotype profile of ABCB1 (MDR1) gene polymorphisms in macedonian population
The aim of this study was to evaluate the most common ABCB1 (MDR1, P-glycoprotein)
polymorphisms in the population of R. Macedonia and compare the allele and haplotype …
polymorphisms in the population of R. Macedonia and compare the allele and haplotype …
ABCB1 single nucleotide polymorphisms in the Brazilian population
MAM Scheiner, AM Damasceno, RC Maia - Molecular biology reports, 2010 - Springer
Abstract The ABCB1/MDR-1 gene, which encodes P-glycoprotein, is highly polymorphic. We
analyzed 278 healthy Brazilian individuals through PCR–RFLP to identify ABCB1 variants …
analyzed 278 healthy Brazilian individuals through PCR–RFLP to identify ABCB1 variants …
Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever
The P-gp/MDR1 multidrug transporter mediates detoxification of numerous drugs, including
colchicine, and CYP3A4 is key to the biotransformation of colchicine. We investigated the …
colchicine, and CYP3A4 is key to the biotransformation of colchicine. We investigated the …