[HTML][HTML] Computation-aided studies related to the induction of specialized metabolite biosynthesis in microbial co-cultures: An introductory overview

T Boruta - Computational and Structural Biotechnology Journal, 2023 - Elsevier
Co-cultivation is an effective method of inducing the production of specialized metabolites
(SMs) in microbial strains. By mimicking the ecological interactions that take place in natural …

[HTML][HTML] Natural product discovery in soil actinomycetes: unlocking their potential within an ecological context

JK Schniete, LT Fernández-Martínez - Current Opinion in Microbiology, 2024 - Elsevier
Highlights•Soil actinomycete genomes contain large numbers of BGCs encoding unknown
NPs.•Most BGCs remain silent under standard laboratory growth conditions.•Matching a …

AC-BioSD: A biomolecular signal differentiator module with enhanced performance (extended version)

E Alexis, JL Avalos, L Cardelli, A Papachristodoulou - bioRxiv, 2024 - biorxiv.org
Temporal gradient estimation is a pervasive phenomenon in natural biological systems and
holds great promise for synthetic counterparts with broad-reaching applications. Here, we …

AC-BioSD: A biomolecular signal differentiator module with enhanced performance

E Alexis, JL Avalos, L Cardelli… - IEEE Control Systems …, 2024 - ieeexplore.ieee.org
Temporal gradient estimation is a pervasive phenomenon in natural biological systems and
holds great promise for synthetic counterparts with broad-reaching applications. Here, we …

Cybernetic control of a natural microbial co-culture

TA Lee, J Morlock, J Allan, H Steel - bioRxiv, 2024 - biorxiv.org
A key obstacle in the widespread application of microbial co-cultures in bioprocesses is their
compositional instability, as faster-growing species outcompete and dominate the culture …