Premature ovarian insufficiency is a complex and relatively poorly understood entity with a
myriad of etiologies and multisystem sequelae that stem from premature deprivation of …

Across the Western World there is an increasing trend to postpone childbearing.
Consequently, the negative influence of age on oocyte quality may lead to a difficulty in …

Premature ovarian insufficiency (POI) affects 1% of women and is a leading cause of
infertility. It is often considered to be a monogenic disorder, with pathogenic variants in~ 100 …

Primary ovarian insufficiency (POI) is characterized by a loss of ovarian function before the
age of 40 and account for one major cause of female infertility. POI relevance is continuously …

There are large variations in the number of oocytes within each woman, and biologically, the
total quantity is at its maximum before the woman is born. Scientific knowledge is limited …

This is a short review of the basic molecular mechanisms of ovarian aging, written with a
particular focus on the use of this data to improve the diagnostic and therapeutic protocols …

Cardiovascular disease (CVD) remains the leading cause of death in women in the United
States and globally, with heart disease actually on the rise among middle-aged women in …

Growth and differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are
oocyte-secreted factors with a leading role in the control of ovarian function in female …

Premature ovarian insufficiency (POI) is defined as a cessation of ovarian function before the
age of 40 years. It is associated with hypoestrogenism and loss of residual follicles, both of …

Context: Idiopathic primary ovarian insufficiency (POI) is a major cause of amenorrhea and
infertility. POI affects 1% of women before age 40 years, and several genetic causes have …