Angiogenesis is crucial during many physiological processes and is influenced by various
biochemical and biomechanical factors. Models have proved useful in understanding the …

Abstract Vascular Endothelial Growth Factor (VEGF) signal transduction is central to
angiogenesis in development and in pathological conditions such as cancer, retinopathy …

VEGF is a key promoter of angiogenesis and a major target of proangiogenic therapy for
peripheral arterial disease (PAD). Greater understanding of VEGF angiogenic signaling and …

Abstract Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) is a pro-angiogenic
receptor, expressed on endothelial cells (ECs). Although biochemical pathways that follow …

The endothelial nitric oxide synthase (eNOS) signaling pathway in endothelial cells has
multiple physiological significances. It produces nitric oxide (NO), an important vasodilator …

Experimental data indicates that soluble vascular endothelial growth factor (VEGF) receptor
1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by VEGF-A. To …

Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis, the growth of
new capillaries from existing microvasculature. In peripheral arterial disease (PAD), lower …

A number of experiments on mouse tumor models, as well as certain clinical data, have
demonstrated, that antiangiogenic therapy can lead to transient improvement in tumor …

Background Negative pressure wound therapy (NPWT) is commonly used to accelerate
wound healing, especially following thoracic surgery; however, the mechanism remains …

The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …