Endothelial cells (ECs) exhibit dramatic plasticity of form at the single-and collective-cell
level during new vessel growth, adult vascular homeostasis, and pathology. Understanding …

The vascular network carries blood throughout the body, delivering oxygen to tissues and
providing a pathway for communication between distant organs. The network is hierarchical …

Understanding the fundamental organisational principles underlying the complex and
multilayered process of angiogenesis is the mutual aim of both the experimental and …

The induction of angiogenesis is a promising therapeutic strategy for the amelioration of
peripheral arterial disease (PAD). This occlusive disease results in muscle ischemia, and …

Tumor growth and progression are critically dependent on the establishment of a vascular
support system. This is often accomplished via the expression of pro-angiogenic growth …

Background This work tests the hypothesis that increased levels of vascular endothelial
growth factor (VEGF) observed during bladder inflammation modulates nerve plasticity …

We simulate the dynamics of a growing, vascular tumor with a heterogeneous vasculature
and its behaviour under combination chemotherapy. The studied model includes two spatial …

Recent findings indicate that VEGF receptors and coreceptors (neuropilins; NRP) are
expressed on nonendothelial cells in human bladder urothelium, in one human bladder …

Cells interact with the extracellular environment by means of receptor molecules on their
surface. Receptors can bind different ligands, leading to the formation of receptor–ligand …

One of the relatively new modalities in treatment of cancer is antiangiogenic therapy (AAT),
which stops the formation of new blood vessels, thus leading to nutrient deprivation of a …