[HTML][HTML] Scientific rationale for developing potent RBD-based vaccines targeting COVID-19

H Kleanthous, JM Silverman, KW Makar, IK Yoon… - npj Vaccines, 2021 - nature.com
Vaccination of the global population against COVID-19 is a great scientific, logistical, and
moral challenge. Despite the rapid development and authorization of several full-length …

Advances in SARS-CoV-2 receptor-binding domain-based COVID-19 vaccines

X Guan, Y Yang, L Du - Expert review of vaccines, 2023 - Taylor & Francis
ABSTRACT Introduction The Coronavirus Disease 2019 (COVID-19) pandemic has caused
devastating human and economic costs. Vaccination is an important step in controlling the …

SARS-CoV-2 receptor binding domain displayed on HBsAg virus–like particles elicits protective immunity in macaques

NC Dalvie, LH Tostanoski, SA Rodriguez-Aponte… - Science …, 2022 - science.org
Authorized vaccines against SARS-CoV-2 remain less available in low-and middle-income
countries due to insufficient supply, high costs, and storage requirements. Global immunity …

[HTML][HTML] An engineered SARS-CoV-2 receptor-binding domain produced in Pichia pastoris as a candidate vaccine antigen

M Limonta-Fernández, G Chinea-Santiago… - New …, 2022 - Elsevier
Developing affordable and easily manufactured SARS-CoV-2 vaccines will be essential to
achieve worldwide vaccine coverage and long-term control of the COVID-19 pandemic …

[HTML][HTML] Enabling growth-decoupled Komagataella phaffii recombinant protein production based on the methanol-free PDH promoter

N Bernat-Camps, K Ebner, V Schusterbauer… - … in Bioengineering and …, 2023 - frontiersin.org
The current transition towards the circular bioeconomy requires a rational development of
biorefineries to sustainably fulfill the present demands. The use of Komagataella phaffii …

RBD-VLP vaccines adjuvanted with Alum or SWE protect K18-hACE2 mice against SARS-CoV-2 VOC challenge

TY Wong, BP Russ, KS Lee, OA Miller, J Kang… - Msphere, 2022 - Am Soc Microbiol
The ongoing COVID-19 pandemic has contributed largely to the global vaccine disparity.
Development of protein subunit vaccines can help alleviate shortages of COVID-19 vaccines …

[HTML][HTML] Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

E Nanishi, F Borriello, HS Seo, TR O'Meara… - npj Vaccines, 2023 - nature.com
Abstract Development of SARS-CoV-2 vaccines that protect vulnerable populations is a
public health priority. Here, we took a systematic and iterative approach by testing several …

Identification of a novel growth-associated promoter for biphasic expression of heterogenous proteins in Pichia pastoris

Q Shen, J Cui, Y Wang, ZC Hu, YP Xue… - Applied and …, 2024 - Am Soc Microbiol
Pichia pastoris (P. pastoris) is one of the most popular cell factories for expressing
exogenous proteins and producing useful chemicals. The alcohol oxidase 1 promoter …

Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG …

S Bajoria, K Kaur, OS Kumru, G Van Slyke… - Human vaccines & …, 2022 - Taylor & Francis
Low-cost, refrigerator-stable COVID-19 vaccines will facilitate global access and improve
vaccine coverage in low-and middle-income countries. To this end, subunit-based …

From Lab to Table: the path of recombinant milk proteins in transforming dairy production.

IN Piazenski, JPM Candelário, VT Soccol… - Trends in Food Science …, 2024 - Elsevier
Background Recombinant milk protein production is emerging as a pivotal innovation in the
dairy industry, driven by the need for sustainable and ethically produced dairy alternatives …