Endocrine therapy is a standard treatment offered to patients with ERα (estrogen receptor α)-
positive breast cancer. In endocrine therapy, ERα is either directly targeted by anti-estrogens …

The tumor suppressor p53 is critical for maintenance of genome stability and protection
against tumor malignant transformation, and its homeostasis is usually regulated by …

Podocyte damage is a major pathological lesion leading to focal segmental
glomerulosclerosis (FSGS). Podocytes damaged by cellular stress undergo hypertrophy to …

Objectives The study aims to analyze the expression of N6-methyladenosine (m6A)-
modified genes in rectum adenocarcinoma (READ) and identify reliable prognostic …

Background Globally, gastric cancer (GC) is a common and lethal solid malignant tumor.
Identifying the molecular signature and its functions can provide mechanistic insights into …

Diepoxybutane (DEB) is the most toxic metabolite of the environmental chemical 1, 3‐
butadiene. We previously demonstrated the occurrence of DEB‐induced p53‐mediated …

Throughout adulthood neural stem cells divide in neurogenic niches–the dentate gyrus of
the hippocampus and the subventricular zone–producing progenitor cells and new neurons …

В настоящее время актуальным является изучение одновременного комбинированного
воздействия химических веществ на развитие негативных эффектов со стороны …

Lycorine, a benzylphenanthridine-type alkaloid extracted form Amarillidaceae genera,
exhibits an efficacy against various types of cancer. Nonetheless, the impact of lycorine …

Undernourishment is defined as the pathological state resulting from a diet deficient in one
or more essential nutrients or from poor assimilation of food. In human populations that have …