Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical Reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Synergistic antibacterial strategy based on photodynamic therapy: Progress and perspectives

X Hu, H Zhang, Y Wang, BC Shiu, JH Lin… - Chemical Engineering …, 2022 - Elsevier
The dramatic increase in drug resistant bacteria resistance to existing conventional
antibiotics poses a great challenge to the effective treatment of infectious diseases …

Clinical development of metal complexes as photosensitizers for photodynamic therapy of cancer

J Karges - Angewandte Chemie International Edition, 2022 - Wiley Online Library
Cancer has emerged over the last decades as one of the deadliest diseases in the world.
Among the most commonly used techniques (ie surgery, immunotherapy, radiotherapy or …

Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

C Li, Y Pang, Y Xu, M Lu, L Tu, Q Li… - Chemical Society …, 2023 - pubs.rsc.org
Metal agents have made incredible strides in preclinical research and clinical applications in
recent years, but their short emission/absorption wavelengths continue to be a barrier to …

Heavy-atom-free photosensitizers: from molecular design to applications in the photodynamic therapy of cancer

VN Nguyen, Y Yan, J Zhao, J Yoon - Accounts of chemical …, 2020 - ACS Publications
Conspectus Photodynamic therapy (PDT) is a clinically approved therapeutic modality that
has shown great potential for the treatment of cancers owing to its excellent spatiotemporal …

Luminescent first-row transition metal complexes

C Wegeberg, OS Wenger - Jacs Au, 2021 - ACS Publications
Precious and rare elements have traditionally dominated inorganic photophysics and
photochemistry, but now we are witnessing a paradigm shift toward cheaper and more …

Photodecaging of a mitochondria-localized iridium (III) endoperoxide complex for two-photon photoactivated therapy under hypoxia

S Kuang, F Wei, J Karges, L Ke, K Xiong… - Journal of the …, 2022 - ACS Publications
Despite the clinical success of photodynamic therapy (PDT), the application of this medical
technique is intrinsically limited by the low oxygen concentrations found in cancer tumors …

Near-infrared-activated anticancer platinum (IV) complexes directly photooxidize biomolecules in an oxygen-independent manner

Z Deng, H Li, S Chen, N Wang, G Liu, D Liu, W Ou… - Nature Chemistry, 2023 - nature.com
Conventional light-driven cancer therapeutics require oxygen and visible light to indirectly
damage biomolecules, limiting their efficacy in deep, hypoxic tumours. Here we report the …

Long wavelength–emissive Ru (II) metallacycle–based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment

Y Xu, C Li, X Ma, W Tuo, L Tu, X Li… - Proceedings of the …, 2022 - National Acad Sciences
Ruthenium (Ru) complexes are developed as latent emissive photosensitizers for cancer
and pathogen photodiagnosis and therapy. Nevertheless, most existing Ru complexes are …

Photosensitizers for photodynamic therapy

M Lan, S Zhao, W Liu, CS Lee… - Advanced healthcare …, 2019 - Wiley Online Library
As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes
advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by …