Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed
based on multi-target directed ligands (MTLDs) paradigm, synthesized and evaluated in …

The enzyme butyrylcholinesterase (BChE) and the human cannabinoid receptor 2 (h CB2R)
represent promising targets for pharmacotherapy in the later stages of Alzheimer's disease …

Non-Alzheimer's dementias constitute 30% of all dementias and present with major
cognitive and behavioral disturbances. Cholinesterase inhibitors improve memory by …

The mitochondria‐targeting drugs can be conventionally divided into the following groups:
those compensating for the energy deficit involved in neurodegeneration, including …

Notwithstanding the combination of cholinesterase (ChE) inhibition and calcium channel
blockade within a multitarget therapeutic approach is envisaged as potentially beneficial to …

A series of rivastigmine-caffeic acid and rivastigmine-ferulic acid hybrids were designed,
synthesized, and evaluated as multifunctional agents for Alzheimer's disease (AD) in vitro …

A new series of conjugates of aminoadamantane and γ-carboline, which are basic scaffolds
of the known neuroactive agents, memantine and dimebon (Latrepirdine) was synthesized …

Highlights•BChE is considered a promising drug target for the treatment of moderate to
severe Alzheimer's disease.•The development of selective BChE inhibitors will move on …

Chronic dietary ingestion of suitable phytochemicals may assist with limiting or negating
neurodegenerative decline. Current therapeutics used to treat Alzheimer disease elicit …

In this work, new sulfonylhydrazone compounds with alkyl derivatives (SH1–SH4 series)
were synthesized via a green chemistry method, and their inhibition effects on …